Flow Cytometry of human ER beta on BT474 Cells. Black: Cells alone; Grey: Isotype Control; Green: Alexa Fluor® 488-labeled ER beta Monoclonal Antibody (Erb455).
Flow Cytometry of human ER beta on BT474 Cells. Black: Cells alone; Grey: Isotype Control; Green: Alexa Fluor® 488-labeled ER beta Monoclonal Antibody (Erb455).

Anti-ER-beta1 Antibody Clone ERb455

$ 298.00
Please Select Product Options Below To View The Catalog Number.

SKU: 2100-MSM1
Species: Human, Monkey, Mouse, Rat, Pig, Horse, and Sheep
Tested Applications: Flow Cytometry, Immunofluorescence, Western Blot, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2a
Mass Spec Validated?: Not MS Validated

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In Stock: 1-2 Day Lead Time.
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: 2100-MSM1-P1
ER-beta1 General Information
Alternate Names
Estrogen receptor beta, ER-?, ERbeta, ER beta, NR3A2, nuclear receptor subfamily 3, group A, member 2, ESR2
Molecular Weight
53-59kDa
Chromosomal Location
14q23.2
Curated Database and Bioinformatic Data
Gene SymbolESR2
Entrez Gene ID2100
Ensemble Gene IDENSG00000140009
RefSeq Protein Accession(s)XP_016876568, XP_016876571, NP_001035365, NP_001201831, NP_001258806, XP_016876569, XP_016876573, XP_016876572, NP_001258805, NP_001278641, NP_001278652, XP_016876570, NP_001428
RefSeq mRNA Accession(s)NM_001214902, NM_001271876, NM_001437, NR_073497, XM_017021080, XM_017021083, XM_017021082 NM_001291723, NM_001040276, XR_001750187, NM_001291712, NM_001040275, NM_001271877, NM_001214903, XM_017021079, XM_017021081, XM_017021084, NR_073496
RefSeq Genomic Accession(s)NC_000014, NG_011535, NC_018925
UniProt ID(s)Q7LCB3, F1D8N3, Q92731, Q0PTK2
UniGene ID(s)Q7LCB3, F1D8N3, Q92731, Q0PTK2
HGNC ID(s)3468
Cosmic ID(s)ESR2
KEGG Gene ID(s)hsa:2100
PharmGKB ID(s)PA27886
General Description of ER-beta1.
Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha, ER-beta, contain DNA binding, ligand binding domains, are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane, can be rapidly activated by exposure of cells to estrogen. ER-alpha, ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation, the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha, ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.

Human, Monkey, Mouse, Rat, Pig, Horse, and Sheep Anti-ER-beta1 Antibody Product Attributes

Species: Human, Monkey, Mouse, Rat, Pig, Horse, and Sheep
Tested Applications: Flow Cytometry, Immunofluorescence, Western Blot, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (0.5-1ug of antibody/ml), Western Blot (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-ER-beta1 Antibody Clone: ERb455
Clone ERb455 Host and Isotype: Mouse IgG2a
Anti-Human, Monkey, Mouse, Rat, Pig, Horse, and Sheep ER-beta1 Positive Control Sample: MCF-7 Cells. Ovarian, Breast, Bladder, Gastric or Salivary carcinoma
Cellular Localization of Antibody Predominantly nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: C-terminus fragment of recombinant human estrogen receptor beta protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

ER-beta1 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-ESR2 antibody staining is expected to be primarily localized to the nucleoplasm.

Limitations and Warranty

enQuire Bio's ER-beta1 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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