Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with ER-beta1 Monoclonal Antibody (ESR2/686).
Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with ER-beta1 Monoclonal Antibody (ESR2/686).Flow Cytometry of human ER beta on BT474 Cells. Black: Cells alone; Grey: Isotype Control; Green: AF488-labeled ER beta1 Monoclonal Antibody (ESR2/686).Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with ER-beta1 Monoclonal Antibody (ESR2/686).Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with ER-beta1 Monoclonal Antibody (ESR2/686).Flow Cytometry for human ER-beta on MCF-7 Cells. Black: Cells alone; Green: Isotype Control; Red: PE-labeled ER-beta1 Monoclonal Antibody (ESR2/686).

Anti-ER-beta1 Antibody Clone ESR2/686

$ 429.00
Please Select Product Options Below To View The Catalog Number.

SKU: 2100-MSM2
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Western Blot, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2a
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
2100-MSM2-P1 Size: 100 ug, Tag: Unconjugated
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In Stock.
Flat Rate Shipping Anywhere in the US: $45
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SKU: 2100-MSM2-P1
ER-beta1 General Information
Alternate Names
Estrogen receptor beta, ER-?, ERbeta, ER beta, NR3A2, nuclear receptor subfamily 3, group A, member 2, ESR2
Molecular Weight
Chromosomal Location
Curated Database and Bioinformatic Data
Gene SymbolESR2
Entrez Gene ID2100
Ensemble Gene IDENSG00000140009
RefSeq Protein Accession(s)XP_016876568, XP_016876571, NP_001035365, NP_001201831, NP_001258806, XP_016876569, XP_016876573, XP_016876572, NP_001258805, NP_001278641, NP_001278652, XP_016876570, NP_001428
RefSeq mRNA Accession(s)NM_001214902, NM_001271876, NM_001437, NR_073497, XM_017021080, XM_017021083, XM_017021082 NM_001291723, NM_001040276, XR_001750187, NM_001291712, NM_001040275, NM_001271877, NM_001214903, XM_017021079, XM_017021081, XM_017021084, NR_073496
RefSeq Genomic Accession(s)NC_000014, NG_011535, NC_018925
UniProt ID(s)Q7LCB3, F1D8N3, Q92731, Q0PTK2
UniGene ID(s)Q7LCB3, F1D8N3, Q92731, Q0PTK2
HGNC ID(s)3468
Cosmic ID(s)ESR2
KEGG Gene ID(s)hsa:2100
PharmGKB ID(s)PA27886
General Description of ER-beta1.
Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha, ER-beta, contain DNA binding, ligand binding domains, are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane, can be rapidly activated by exposure of cells to estrogen. ER-alpha, ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation, the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha, ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.

Human Anti-ER-beta1 Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Western Blot, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (0.5-1ug of antibody/ml), Western Blot (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-ER-beta1 Antibody Clone: ESR2/686
Clone ESR2/686 Host and Isotype: Mouse IgG2a
Anti-Human ER-beta1 Positive Control Sample: MCF-7 Cells. Ovarian, Breast, Bladder, Gastric or Salivary carcinoma
Cellular Localization of Antibody Predominantly nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: C-terminus fragment of recombinant human estrogen receptor beta protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

ER-beta1 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-ESR2 antibody staining is expected to be primarily localized to the nucleoplasm.

Limitations and Warranty

enQuire Bio's ER-beta1 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-ER-beta1 Antibody Clone ESR2/686