Formalin-fixed, paraffin-embedded human Spleen stained with ETS1 Monoclonal Antibody (ETS1/1282).
Formalin-fixed, paraffin-embedded human Spleen stained with ETS1 Monoclonal Antibody (ETS1/1282).

Anti-ETS1 Antibody Clone ETS1/1282

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 2113-MSM1
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG
Mass Spec Validated?: Not MS Validated

Size
Tag Clear selection
Shipping Information
In Stock: 1-2 Day Lead Time.
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: 2113-MSM1-P0
ETS1 General Information
Alternate Names
Protein C-ets-1, ETS1
Molecular Weight
54kDa
Chromosomal Location
11q23.3
Curated Database and Bioinformatic Data
Gene SymbolETS1
Entrez Gene ID2113
Ensemble Gene IDENSG00000134954
RefSeq Protein Accession(s)XP_011540954, XP_016872805, NP_001317380, XP_011540952, XP_016872804, NP_005229, XP_011540953, XP_011540951, XP_016872806, NP_001137292, XP_016872803, NP_001155894
RefSeq mRNA Accession(s)XM_017017314, NM_001162422, XM_011542650, NM_005238, XM_011542652, XM_017017317, XM_017017315 NM_001143820, XM_011542649, XM_017017316, XM_011542651, NM_001330451
RefSeq Genomic Accession(s)NG_029555, NC_000011, NC_018922
UniProt ID(s)P14921, B4DW78, A8K725
UniGene ID(s)P14921, B4DW78, A8K725
HGNC ID(s)3488
Cosmic ID(s)ETS1
KEGG Gene ID(s)hsa:2113
PharmGKB ID(s)PA27902
General Description of ETS1.
ETS1 proto-oncogene is an important transcription factor that plays a role in cell proliferation and differentiation. ETS1 is related to the growth of carcinoma cells by its regulation of the transcription of matrix metalloproteinases and urokinase-type plasminogen activator. The processes of tumor invasion and metastasis depend on the increased proteolytic activity of the invading tumor cells that may involve matrix metalloproteinases, cathepsins B and D and plasminogen activator in the metastatic cascade. ETS1 is preferentially expressed in lymphoid cells, where it is essential for the maintenance of the normal pool of resting T and B cells. ETS1 expression level and distribution are differentially controlled in resting, activated and apoptotic lymphocytes.

Human Anti-ETS1 Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-ETS1 Antibody Clone: ETS1/1282
Clone ETS1/1282 Host and Isotype: Mouse IgG
Anti-Human ETS1 Positive Control Sample: HepG2 and HeLa cells. Tonsil, Skin, Pancreas, Kidney and Lymphoma.
Cellular Localization of Antibody Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human ETS1 fragment (aa137-230)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

ETS1 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-ETS1 antibody staining is expected to be primarily localized to the nucleoplasm. There is variability in either the signal strength or the localization of signal in nucleoplasm from cell to cell.

Observed Antibody Staining Data By Tissue Type:

Variations in ETS1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in germinal center cells in the tonsil, hematopoietic cells in the bone marrow, lymphoid tissue in appendix and non-germinal center cells in the lymph node and tonsil. More moderate antibody staining intensity was present in germinal center cells in the tonsil, hematopoietic cells in the bone marrow, lymphoid tissue in appendix and non-germinal center cells in the lymph node and tonsil. Low, but measureable presence of ETS1 could be seen in. We were unable to detect ETS1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of ETS1 expression as measured by anti-ETS1 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - - - ++ + - - - - - - - - -
ETS1 Variability + + + + + + + + + ++ ++ + + + + + + + + +

Limitations and Warranty

enQuire Bio's ETS1 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

There are no reviews yet.

Be the first to review “Anti-ETS1 Antibody Clone ETS1/1282”

Your email address will not be published. Required fields are marked *

Share a Protocol (View Reviewed Protocols Below)

Protocol Title

Materials

Methods

Notes


  protocol submission gif

enQuire Bio, LLC   1825 Lawrence St, Ste 115   Denver, CO 80202
Phone: 1-855-344-1400 | enquire@enquirebio.com | Fax: 1-720-897-3730
Customer Service Available M-F 8AM-6PM MST or 24/7 Via Email

We consume cookies ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are happy with it. Dismiss

Anti-ETS1 Antibody Clone ETS1/1282

https://enquirebio.com/wp-content/uploads/2017/10/enQuire-Bio-2113-MSM1-P0-anti-ETS1-antibody-300x225.jpeg