Immunohistochemical staining of Factor VIII Related /Von Willebrand Factor  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

Factor VIII Related /Von Willebrand Factor [F8/86] Antibody (cGMP).

$ 128.00$ 368.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD57
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG1, kappa

Product NumberDescriptionPrice
QIVD57-0.1ml Size: 0.1 ml, Format: Concentrate $ 128.00
QIVD57-0.5ml Size: 0.5 ml, Format: Concentrate $ 228.00
QIVD57-1ml Size: 1 ml, Format: Concentrate $ 368.00
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Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

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SKU: QIVD57-0.1ml
Factor VIII Related /Von Willebrand Factor General Information
Alternate Names
Molecular Weight
298.4 kDa
Chromosomal Location
p13.31 [chr: 12] [chr_start: 5948874] [chr_end: 6124770] [strand: -1]
Curated Database and Bioinformatic Data
Gene SymbolVWF
Entrez Gene ID7450
RefSeq Protein Accession(s)NP_000543;
RefSeq mRNA Accession(s)NM_000552;
RefSeq Genomic Accession(s)NC_000012; NG_009072
UniProt ID(s)L8E853
KEGG Gene ID(s)hsa:7450
General Description of Factor VIII Related /Von Willebrand Factor .
This antibody reacts with Von Willebrand factor in endothelial cells. It also reacts with megakaryocytes in human bone marrow.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:25-1:50
Pretreatment Enzymatic Antigen Retrieval (eg. Histozyme)
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal
Anti-Factor VIII Related /Von Willebrand Factor Antibody Clone: F8/86
Host and Isotype: Mouse IgG1, kappa
Recommended Positive Control Sample: Tonsil
Cellular Localization of Antibody F8/86 Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Von Willebrand factor isolated from human plasma.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Factor VIII Related /Von Willebrand Factor Information for Pathologists

Summary:

Large glycoprotein involved in platelet aggression and adhesion to subendothelial matrix. Somewhat sensitive (50-75%) for vascular tumors; CD31, CD34 or perhaps FLI1 are more sensitive. Interpretation Cytoplasmic stain. Endothelium should be a positive internal control.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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Factor VIII Related /Von Willebrand Factor [F8/86] Antibody (cGMP).