Antibody (Suitable for clinical applications)
Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
|Recommended Dilution (Conc)||1:50-1:100|
|Pretreatment||Citrate Buffer pH 6.0|
|Incubation Parameters||30 min at Room Temperature|
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Anti-Fascin-1 Antibody Clone: 55k-2
Host and Isotype: Mouse IgG2a, kappa
Recommended Positive Control Sample: Hodgkin s lymphoma, Ovary
Cellular Localization of Antibody 55k-2 Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Full length recombinant human FSCN1 protein.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.
Fascin-1 Information for Pathologists
Summary:Fascin-1 is an actin bundling protein with important role in cell motility and adhesion. High expression in tumors is generally a poor prognostic marker. Fascin-1 is present in specialized cells with extensive surfaces or migratory potential, such as neurons, glia, dendritic cells, macrophages, skeletal and smooth muscle, endothelial cells but is generally absent in normal epithelial cells.
Common Uses By Pathologists:Facin-1 staining is generally observed in carcinoma of biliary tract, breast, colon, lung, ovary, pancreas, and skin. Follicular dendritic cell tumors, Hodgkin lymphoma-classic subtype (highly sensitive), interdigitating dendritic cell tumors, Langerhan cell histiocytosis, and urothelial carcinoma (noninvasive papillary or invasive) also express Fascin-1.
Limitations and Warranty
This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.
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