enQuire-Bio-QAB91-F-100ug-anti-FcERI-FCER1A-antibody-10

Anti-FCER1A Antibody [MAR-1]

$ 49.00$ 199.00
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SKU: QAB91
Species: Mouse
Tested Applications: Flow Cytometry
Available Conjugates: FITC ;Unconjugated ;PE
Isotype: Armenian Hamster IgG
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: QAB91-F-25ug
FcERI / FCER1A General Information
Alternate Names
FcERI, FCER1A, fcepsilonri, Fce1a, FcERI, Fcr-5
Curated Database and Bioinformatic Data
Gene SymbolFCER1A
Entrez Gene ID2205
Ensemble Gene IDENSG00000179639
RefSeq Protein Accession(s)NP_001992
RefSeq mRNA Accession(s)NM_002001
RefSeq Genomic Accession(s)NC_000001, NC_018912
UniProt ID(s)P12319
UniGene ID(s)P12319
HGNC ID(s)3609
Cosmic ID(s)FCER1A
KEGG Gene ID(s)hsa:2205
PharmGKB ID(s)PA28056
General Description of FcERI / FCER1A.
The MAR-1 antibody reacts with the Fc epsilon Receptor I alpha chain (FceRIa), a transmembrane protein member of the Ig superfamily. This chain, together with a beta chain and two gamma chains form a tetrameric complex that supports IgE-mediated signaling and subsequent release of chemical mediators of allergy and immediate hypersensitivity. FceR1a is upregulated in the presence of IgE on those cell types which express it, such as Mast cells and Basophils.The MAR-1 antibody is widely used both in flow cytometry and for depletion of cells in vitro / in vivo. Please choose the appropriate format for each application.

Mouse Anti-FcERI / FCER1A Antibody Product Attributes

Species: Mouse
Tested Applications: Flow Cytometry.
Application Notes: See Product Datasheet for Recommended Dilution Range. Requires Experimental Optimization
Clonality: Monoclonal Antibody
Anti-FcERI / FCER1A Antibody Clone: 42795
Clone 42795 Host and Isotype: Armenian Hamster IgG
Buffer and Stabilizer: 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
Antibody Concentration: 0.5 mg/mL
Storage Conditions: 2-8C protected from light. Stable for 12 Months. Do Not Freeze.

FcERI / FCER1A Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in FcERI / FCER1A antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of FcERI / FCER1A could be seen in cells in the red pulp in spleen, endothelial cells in the colon, epidermal cells in the skin, glandular cells in the adrenal gland, appendix, colon, duodenum, fallopian tube, rectum, seminal vesicle and thyroid gland, hematopoietic cells in the bone marrow, Leydig cells in the testis, melanocytes in skin, myocytes in heart muscle and skeletal muscle, myoepithelial cells in the breast, neuronal cells in the hippocampus, respiratory epithelial cells in the nasopharynx, trophoblastic cells in the placenta and urothelial cells in the urinary bladder. We were unable to detect FcERI / FCER1A in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of FcERI / FCER1A expression as measured by anti-FcERI / FCER1A antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - + - - - - - - - - - - - -
FCER1A Variability ++ ++ + ++ + ++ + ++ + + + + + + + + + + ++ +

Selected References

Mukai K, BenBarak MJ, Tachibana M, Nishida K, Karasuyama H, Taniuchi I, and Galli SJ. 2012. Blood. 120: 76-85. (Flow cytometry)Smith KA, Harcus Y, Garbi N, Hammerling GJ, MacDonald AS, and Maizels RM. 2012. Infect. Immun. 80: 3481-3489. (in vivo depletion)Larson D, Hubner MP, Torrero MN, Morris CP, Brankin A, Swierczewski BE, Davies SJ, Vonakis BM, and Mitre E. 2012. J. Immunol. 188: 4188-4199. (in vitro activation)Khodoun M, Krishnamurthy D, Strait R, Kucuk Y, and Finkelman F. 2011. J. Immunol. 186: 151.4. (in vitro depletion)

Limitations and Warranty

enQuire Bio's Mouse Anti-FCER1A Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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