Formalin-fixed, paraffin-embedded Human Pancreas stained with Ferritin, Light Chain Monoclonal Antibody (FTL/1388).
Formalin-fixed, paraffin-embedded Human Pancreas stained with Ferritin, Light Chain Monoclonal Antibody (FTL/1388).

Anti-Ferritin, Light Chain Antibody Clone FTL/1388

$ 118.00$ 418.00
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SKU: 2512-MSM3
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2a
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 2512-MSM3-P0
Ferritin, Light Chain General Information
Alternate Names
FTL, Ferritin Light Chain
Molecular Weight
19-25kDa
Chromosomal Location
19q13.33
Curated Database and Bioinformatic Data
Gene SymbolFTL
Entrez Gene ID2512
Ensemble Gene IDENSG00000087086
RefSeq Protein Accession(s)NP_000137
RefSeq mRNA Accession(s)NM_000146
RefSeq Genomic Accession(s)NC_000019, NC_018930, NG_008152
UniProt ID(s)P02792
UniGene ID(s)P02792
HGNC ID(s)3999
Cosmic ID(s)FTL
KEGG Gene ID(s)hsa:2512
PharmGKB ID(s)PA28412
General Description of Ferritin, Light Chain.
Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains, ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III). Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts.

Human Anti-Ferritin, Light Chain Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Ferritin, Light Chain Antibody Clone: FTL/1388
Clone FTL/1388 Host and Isotype: Mouse IgG2a
Anti-Human Ferritin, Light Chain Positive Control Sample: HepG2, HeLa, HL-60 or 293T cells. Pancreas, Liver, Cerebellum or Testis.
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human FTL protein fragment (aa 38-165)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Ferritin, Light Chain Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-FTL antibody staining is expected to be primarily localized to the cytosol.

Observed Antibody Staining Data By Tissue Type:

Variations in Ferritin, Light Chain antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the tubules in kidney, glial cells in the caudate nucleus and cerebral cortex, hepatocytes in liver, Leydig cells in the testis, macrophages in lung, neuronal cells in the caudate nucleus and Purkinje cells in the cerebellum. More moderate antibody staining intensity was present in cells in the tubules in kidney, glial cells in the caudate nucleus and cerebral cortex, hepatocytes in liver, Leydig cells in the testis, macrophages in lung, neuronal cells in the caudate nucleus and Purkinje cells in the cerebellum. Low, but measureable presence of Ferritin, Light Chain could be seen in cells in the endometrial stroma in endometrium, cells in the seminiferous ducts in testis, exocrine glandular cells in the pancreas, fibroblasts in skin and mesenchymal tissue, glandular cells in the breast, endometrium, epididymis, prostate, salivary gland, stomach and thyroid gland, Langerhans in skin, myocytes in heart muscle, neuronal cells in the cerebral cortex and hippocampus, respiratory epithelial cells in the nasopharynx, smooth muscle cells in the smooth muscle, squamous epithelial cells in the cervix, uterine, oral mucosa and tonsil, trophoblastic cells in the placenta and urothelial cells in the urinary bladder. We were unable to detect Ferritin, Light Chain in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Ferritin, Light Chain expression as measured by anti-Ferritin, Light Chain antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - + ++ + ++ ++ - ++ - - ++ ++ + - - ++ ++
FTL Variability ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ +++

Limitations and Warranty

enQuire Bio's Ferritin, Light Chain Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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