Formalin-fixed, paraffin-embedded human Skin stained with Filaggrin Monoclonal Antibody (FLG/1561).
Formalin-fixed, paraffin-embedded human Skin stained with Filaggrin Monoclonal Antibody (FLG/1561).

Anti-Filaggrin Antibody Clone FLG/1561

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 2312-MSM1
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 2312-MSM1-P0
Filaggrin General Information
Alternate Names
FLG, Filaggrin, Filament Aggregating rotein
Molecular Weight
26-45kDa (Processed) ;350kDa (Profilaggrin)
Chromosomal Location
1q21.3
Curated Database and Bioinformatic Data
Gene SymbolFLG
Entrez Gene ID2312
Ensemble Gene IDENSG00000143631
RefSeq Protein Accession(s)NP_002007
RefSeq mRNA Accession(s)NM_002016,
RefSeq Genomic Accession(s)NG_016190, NC_000001, NC_018912
UniProt ID(s)P20930
UniGene ID(s)P20930
HGNC ID(s)3748
Cosmic ID(s)FLG
KEGG Gene ID(s)hsa:2312
PharmGKB ID(s)PA28169
General Description of Filaggrin.
Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

Human Anti-Filaggrin Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Filaggrin Antibody Clone: FLG/1561
Clone FLG/1561 Host and Isotype: Mouse IgG1
Anti-Human Filaggrin Positive Control Sample: U-251-MG cells or Skin
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human Filaggrin protein fragment (aa 998-1104)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Filaggrin Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-FLG antibody staining is expected to be primarily localized to the vesicles.

Observed Antibody Staining Data By Tissue Type:

Variations in Filaggrin antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in epidermal cells in the skin. More moderate antibody staining intensity was present in epidermal cells in the skin. Low, but measureable presence of Filaggrin could be seen infibroblasts in skin, melanocytes in skin, squamous epithelial cells in the cervix and uterine. We were unable to detect Filaggrin in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's Filaggrin Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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