Formalin-fixed, paraffin-embedded human Pituitary stained with FSH-beta Monoclonal Antibody (SPM17).
Formalin-fixed, paraffin-embedded human Pituitary stained with FSH-beta Monoclonal Antibody (SPM17).

Anti-FSH-beta Antibody Clone SPM107

$ 298.00
Please Select Product Options Below To View The Catalog Number.

SKU: 2488-MSM1X
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 2488-MSM1X-P1
FSH-beta General Information
Alternate Names
Follitropin subunit beta, follicle-stimulating hormone beta subunit, FSH-B, FSHB
Molecular Weight
22kDa
Chromosomal Location
11p13
Curated Database and Bioinformatic Data
Gene SymbolFSHB
Entrez Gene ID2488
Ensemble Gene IDENSG00000131808
RefSeq Protein Accession(s)NP_000501, NP_001018090
RefSeq mRNA Accession(s)NM_001018080 NM_000510
RefSeq Genomic Accession(s)NC_018922, NG_008144, NC_000011
UniProt ID(s)P01225, A0A0F7RQE8
UniGene ID(s)P01225, A0A0F7RQE8
HGNC ID(s)3964
Cosmic ID(s)FSHB
KEGG Gene ID(s)hsa:2488
PharmGKB ID(s)PA28382
General Description of FSH-beta.
This MAb reacts with a protein of 22kDa, identified as beta sub-unit of FSH. It does not cross react with the alpha sub-unit. Follicle stimulating hormone (FSH) is a hormone synthesized, secreted by gonadotrophs in the anterior pituitary gland. In the ovary, FSH stimulates the growth of immature Graafian follicles to maturation. As the follicle grows, it releases inhibin, which deactivates the FSH production. In men, FSH enhances the production of,rogen-binding protein by the Sertoli cells of the testis, is critical for spermatogenesis. FSH, LH act synergistically in reproduction. FSH is a useful marker in the classification of pituitary tumors, the study of pituitary disease.

Human Anti-FSH-beta Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml, 30 min RT)
Clonality: Monoclonal
Anti-FSH-beta Antibody Clone: SPM107
Clone SPM107 Host and Isotype: Mouse IgG1 kappa
Anti-Human FSH-beta Positive Control Sample: Anterior Pituitary
Cellular Localization of Antibody Cytoplasmic, secreted
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Full length purified Human FSH
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

FSH-beta Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in FSH-beta antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the anterior in pituitary gland. More moderate antibody staining intensity was present in cells in the anterior in pituitary gland. Low, but measureable presence of FSH-beta could be seen in. We were unable to detect FSH-beta in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's FSH-beta Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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