Formalin-fixed, paraffin-embedded human Fetal Liver stained with Glypican-3 Recombinant Rabbit Monoclonal Antibody (GPC3/1534R)
Formalin-fixed, paraffin-embedded human Fetal Liver stained with Glypican-3 Recombinant Rabbit Monoclonal Antibody (GPC3/1534R)

Anti-Glypican-3 Antibody Clone GPC3/1534R

$ 228.00$ 618.00
Please Select Product Options Below To View The Catalog Number.

SKU: 2719-RBM4
Species: Human and Rat
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Rabbit IgG kappa
Mass Spec Validated?: Not MS Validated

Size
Tag Clear selection
Shipping Information
In Stock: 1-2 Day Lead Time.
Flat Rate Shipping Anywhere in France: €50
Datasheets and Documentation
Product Datasheet
SKU: 2719-RBM4-P0
Glypican-3 General Information
Alternate Names
Glypican-3, GPC3
Molecular Weight
67kDa
Chromosomal Location
Xq26.2
Curated Database and Bioinformatic Data
Gene SymbolGPC3
Entrez Gene ID2719
Ensemble Gene IDENSG00000147257
RefSeq Protein Accession(s)XP_016884902, NP_001158090, NP_001158089, NP_001158091, NP_004475
RefSeq mRNA Accession(s)XM_017029413, NM_001164618, NM_001164617, NM_004484 NM_001164619
RefSeq Genomic Accession(s)NC_018934, NG_009286, NC_000023
UniProt ID(s)Q53H15, B4DTD8, I6QTG3, P51654
UniGene ID(s)Q53H15, B4DTD8, I6QTG3, P51654
HGNC ID(s)4451
Cosmic ID(s)GPC3
KEGG Gene ID(s)hsa:2719
PharmGKB ID(s)PA28832
General Description of Glypican-3.
Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilm s tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression is also found in some types of embryonal tumors, such as Wilm s tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma.

Human and Rat Anti-Glypican-3 Antibody Product Attributes

Species: Human and Rat
Tested Applications: Immunohistochemistry (IHC).
Clonality: Recombinant Monoclonal
Anti-Glypican-3 Antibody Clone: GPC3/1534R
Clone GPC3/1534R Host and Isotype: Rabbit IgG kappa
Anti-Human and Rat Glypican-3 Positive Control Sample: 293T cells or Hepatocellular carcinoma
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with or without 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length GPC3 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Glypican-3 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-GPC3 antibody staining is expected to be primarily localized to the plasma membrane.

Limitations and Warranty

enQuire Bio's Glypican-3 Recombinant Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

There are no reviews yet.

Be the first to review “Anti-Glypican-3 Antibody Clone GPC3/1534R”

Your email address will not be published. Required fields are marked *

Share a Protocol (View Reviewed Protocols Below)

Protocol Title

Materials

Methods

Notes


  protocol submission gif

enQuire Bio, LLC   1825 Lawrence St, Ste 115   Denver, CO 80202
Phone: 1-855-344-1400 | enquire@enquirebio.com | Fax: 1-720-897-3730
Customer Service Available M-F 8AM-6PM MST or 24/7 Via Email
Scroll to top

We consume cookies ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are happy with it. Dismiss

Anti-Glypican-3 Antibody Clone GPC3/1534Rhttps://enquirebio.com/wp-content/uploads/2017/10/enQuire-Bio-2719-RBM4-P0-anti-Glypican-3-antibody-300x225.jpeg