Data from SDS-PAGE analysis of Anti-Glypican-3 antibody (Clone rGPC3/863). Reducing lane (R) shows heavy and light chain fragments. NR lane shows intact antibody with expected MW of approximately 150 kDa. The data are consistent with a high purity, intact mAb.Formalin-fixed, paraffin-embedded human Hepatocellular Carcinoma stained with Glypican-3 Recombinant Mouse Monoclonal Antibody (rGPC3/863).

Anti-Glypican-3 Antibody Clone rGPC3/863

$ 228.00$ 518.00
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SKU: 2719-MSM6
Species: Human and Rat
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
2719-MSM6-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
2719-MSM6-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
2719-MSM6-P2 Size: 200 ug, Tag: Unconjugated $ 459.00
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Datasheets and Documentation
Product Datasheet
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SKU: 2719-MSM6-P0
Glypican-3 General Information
Alternate Names
Glypican-3, GPC3
Molecular Weight
Chromosomal Location
Curated Database and Bioinformatic Data
Gene SymbolGPC3
Entrez Gene ID2719
Ensemble Gene IDENSG00000147257
RefSeq Protein Accession(s)XP_016884902, NP_001158090, NP_001158089, NP_001158091, NP_004475
RefSeq mRNA Accession(s)XM_017029413, NM_001164618, NM_001164617, NM_004484 NM_001164619
RefSeq Genomic Accession(s)NC_018934, NG_009286, NC_000023
UniProt ID(s)Q53H15, B4DTD8, I6QTG3, P51654
UniGene ID(s)Q53H15, B4DTD8, I6QTG3, P51654
HGNC ID(s)4451
Cosmic ID(s)GPC3
KEGG Gene ID(s)hsa:2719
PharmGKB ID(s)PA28832
General Description of Glypican-3.
Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilm s tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression is also found in some types of embryonal tumors, such as Wilm s tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma.

Human and Rat Anti-Glypican-3 Antibody Product Attributes

Species: Human and Rat
Tested Applications: Immunohistochemistry (IHC).
Clonality: Recombinant Monoclonal
Anti-Glypican-3 Antibody Clone: rGPC3/863
Clone rGPC3/863 Host and Isotype: Mouse IgG1 kappa
Anti-Human and Rat Glypican-3 Positive Control Sample: 293T cells or Hepatocellular carcinoma
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with or without 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant full-length human GPC3 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Glypican-3 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-GPC3 antibody staining is expected to be primarily localized to the plasma membrane.

Limitations and Warranty

enQuire Bio's Glypican-3 Recombinant Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Glypican-3 Antibody Clone rGPC3/863 Specificity Assay (Array)-300x120.jpg IHC human Hepatocellular Carcinoma (rGPC3 863)-300x225.jpg 863) Gel-241x300.jpg