Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with GnRH-Receptor Monoclonal Antibody (F1G4)
Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with GnRH-Receptor Monoclonal Antibody (F1G4)

Anti-GnRH-Receptor / LH-RH Receptor Antibody Clone F1G4; same as GNRH03

$ 298.00
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SKU: 2798-MSM1
Species: Human and Rat
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Shipping Information
In Stock: 1-2 Day Lead Time.
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Datasheets and Documentation
Product Datasheet
SKU: 2798-MSM1-P1
GnRH-Receptor / LH-RH Receptor General Information
Alternate Names
Gonadotropin-releasing hormone receptor, GNRHR, LHCGR, Luteinizing hormone / Choriogonadotropin receptor, Lutropin / Choriogonadotropin receptor, LCGR, Luteinizing Hormone Receptor (LHR)
Molecular Weight
54-60kDa
Chromosomal Location
4q21.2 (GNRHR) & 2p16.3 (LHCGR) (Human)
Curated Database and Bioinformatic Data
Gene SymbolGNRHR, LHCGR
Entrez Gene ID2798, 3973
Ensemble Gene IDENSG00000109163, ENSG00000138039
RefSeq Protein Accession(s)NP_000397, NP_001012781, XP_006712078, XP_011531133, XP_016859579, XP_005264366, XP_011531136, XP_016859578, XP_011531130, NP_000224
RefSeq mRNA Accession(s)NM_000406 NM_001012763, XM_011532828, XM_011532831, XM_017004090, XM_011532834, XM_006712015, XM_017004089, NM_000233
RefSeq Genomic Accession(s)NC_000004, NC_018915, NG_009293, NG_008193, NG_033050, NC_000002, NC_018913
UniProt ID(s)P30968, P22888
UniGene ID(s)P30968, P22888
HGNC ID(s)4421, 6585
Cosmic ID(s)GNRHR, LHCGR
KEGG Gene ID(s)hsa:2798, hsa:3973
PharmGKB ID(s)PA28800, PA30357
General Description of GnRH-Receptor / LH-RH Receptor.
Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis, ovulation by stimulating the testes, ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen, progesterone levels during the first trimester of pregnancy. Ovaries, testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular, intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy, Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal, granulosa cells as well as in ovarian cell membrane preparations.

Human and Rat Anti-GnRH-Receptor / LH-RH Receptor Antibody Product Attributes

Species: Human and Rat
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (1-2ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-GnRH-Receptor / LH-RH Receptor Antibody Clone: F1G4; same as GNRH03
Clone F1G4; same as GNRH03 Host and Isotype: Mouse IgG1 kappa
Anti-Human and Rat GnRH-Receptor / LH-RH Receptor Positive Control Sample: T47D cells. Pituitary gland, ovarian or breast cancers.
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: A synthetic peptide aa 1-29 (MANSASPEQNQHCSAINNSIPLMQGNLPY) from the N-terminal of human GnRH receptor.
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

GnRH-Receptor / LH-RH Receptor Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's GnRH-Receptor / LH-RH Receptor Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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