Formalin-fixed, paraffin-embedded human Pancreas stained with GP2 Monoclonal Antibody (GP2/1712).
Formalin-fixed, paraffin-embedded human Pancreas stained with GP2 Monoclonal Antibody (GP2/1712).

Anti-GP2 Antibody Clone GP2/1712

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 2813-MSM2
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 2813-MSM2-P0
GP2 General Information
Alternate Names
Pancreatic secretory granule membrane major glycoprotein GP2, GP2
Molecular Weight
59kDa
Chromosomal Location
16p12
Curated Database and Bioinformatic Data
Gene SymbolGP2
Entrez Gene ID2813
Ensemble Gene IDENSG00000169347
RefSeq Protein Accession(s)NP_001493, XP_016878644, NP_001007243, NP_001007241, NP_001007242
RefSeq mRNA Accession(s)NM_001007241, NM_001007242, NM_001502, XM_017023155, NM_001007240
RefSeq Genomic Accession(s)NC_000016, NC_018927
UniProt ID(s)Q68D34, B7Z1G2, P55259
UniGene ID(s)Q68D34, B7Z1G2, P55259
HGNC ID(s)4441
Cosmic ID(s)GP2
KEGG Gene ID(s)hsa:2813
PharmGKB ID(s)PA28822
General Description of GP2.
GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.

Human Anti-GP2 Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-GP2 Antibody Clone: GP2/1712
Clone GP2/1712 Host and Isotype: Mouse IgG
Anti-Human GP2 Positive Control Sample: PANC-1 cells. Pancreas
Cellular Localization of Antibody Cell Surface and Secreted
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human GP2 protein fragment (aa35-179)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

GP2 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in GP2 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in exocrine glandular cells in the pancreas. More moderate antibody staining intensity was present in exocrine glandular cells in the pancreas. Low, but measureable presence of GP2 could be seen in. We were unable to detect GP2 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of GP2 expression as measured by anti-GP2 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - + - - - - - - - - - - - - - - - -
GP2 Variability ++ + + ++ + + + + + + + + + + + + ++ + + +

Limitations and Warranty

enQuire Bio's GP2 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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