Immunohistochemical staining of Granzyme B  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

Granzyme B [Polyclonal] Antibody (cGMP).

$ 158.00$ 838.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD134
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Rabbit Undetermined

Product NumberDescriptionPrice
QIVD134-0.1ml Size: 0.1 ml, Format: Concentrate $ 158.00
QIVD134-0.5ml Size: 0.5 ml, Format: Concentrate $ 498.00
QIVD134-1ml Size: 1 ml, Format: Concentrate $ 838.00
QIVD134-6ml Size: 6 ml, Format: Predilute $ 298.00
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Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

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SKU: QIVD134-0.1ml
Granzyme B General Information
Alternate Names
Molecular Weight
27.7 kDa
Chromosomal Location
q12 [chr: 14] [chr_start: 24630954] [chr_end: 24634267] [strand: -1]
Curated Database and Bioinformatic Data
Gene SymbolGZMB
Entrez Gene ID3002
RefSeq Protein Accession(s)NP_004122
RefSeq mRNA Accession(s)NM_001346011; NR_144343; NM_004131;
RefSeq Genomic Accession(s)NC_000014; NG_028340
UniProt ID(s)P10144
KEGG Gene ID(s)hsa:3002
General Description of Granzyme B .
This antibody reacts with a 32 kDa protein. Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned. Human granzyme B is involved in target cell apoptosis during lymphocyte-mediated cytotoxicity. This antibody is useful in the localization of granzyme B containing lytic granules and for the characterization of activated CTL or NK cells.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:50-1:100
Pretreatment Citrate Buffer pH 6.0
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Polyclonal
Anti-Granzyme B Antibody Clone: Polyclonal
Host and Isotype: Rabbit Undetermined
Recommended Positive Control Sample: Tonsil
Cellular Localization of Antibody Polyclonal Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: A synthetic peptide from the N-terminus of human granzyme B.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Granzyme B Information for Pathologists

Summary:

Enzyme associated with cytotoxic T lymphocytes; induces apoptosis in target cells of these lymphocytes.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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Granzyme B [Polyclonal] Antibody (cGMP).