Formalin-fixed, paraffin-embedded Rat Pancreas stained with Histone H1 Mouse Recombinant Monoclonal Antibody (r1415-1)
Formalin-fixed, paraffin-embedded Rat Pancreas stained with Histone H1 Mouse Recombinant Monoclonal Antibody (r1415-1)

Anti-Histone H1 Antibody Clone r1415-1

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 3005-MSM7
Species: Human, Mouse, and Rat
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2a kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 3005-MSM7-P0
Histone H1 General Information
Alternate Names
Histone H1
Molecular Weight
~30kDa
Chromosomal Location
3q21-q22; 6q21-q22; 22q13.1
Curated Database and Bioinformatic Data
Gene SymbolH1
Entrez Gene ID3005
Ensemble Gene IDENSG00000189060
RefSeq Protein Accession(s)NP_005309
RefSeq mRNA Accession(s)NM_005318
RefSeq Genomic Accession(s)NC_000022, NC_018933
UniProt ID(s)P07305
UniGene ID(s)P07305
HGNC ID(s)4714
Cosmic ID(s)H1F0
KEGG Gene ID(s)hsa:3005
PharmGKB ID(s)PA29092
General Description of Histone H1.
Eukaryotic histones are basic and water-soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer; formed of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, sumoylation, ubiquitination and ADP-ribosylation.

Human, Mouse, and Rat Anti-Histone H1 Antibody Product Attributes

Species: Human, Mouse, and Rat
Tested Applications: Immunohistochemistry (IHC).
Clonality: Recombinant Monoclonal
Anti-Histone H1 Antibody Clone: r1415-1
Clone r1415-1 Host and Isotype: Mouse IgG2a kappa
Anti-Human, Mouse, and Rat Histone H1 Positive Control Sample: HeLa, A-431, LNCap or Jurkat cells. Breast carcinoma.
Cellular Localization of Antibody Nuclear
Buffer and Stabilizer: 10mM PBS with or without 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Nuclei of human leukemia biopsy cells
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Histone H1 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-H1F0 antibody staining is expected to be primarily localized to the nuclear bodies and nucleus. There is variability in either the signal strength or the localization of signal in nucleus from cell to cell.

Limitations and Warranty

enQuire Bio's Histone H1 Recombinant Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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