Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with Interferon gamma Monoclonal Antibody (IFNG/466)
Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with Interferon gamma Monoclonal Antibody (IFNG/466)Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with Interferon gamma Monoclonal Antibody (IFNG/466)

Anti-Interferon gamma Antibody Clone IFNG/466

$ 148.00$ 368.00
Please Select Product Options Below To View The Catalog Number.

SKU: 3458-MSM4
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2b kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
3458-MSM4-P0 Size: 20 ug, Tag: Unconjugated $ 118.00
3458-MSM4-P1 Size: 100 ug, Tag: Unconjugated $ 298.00
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SKU: 3458-MSM4-P0
Interferon gamma General Information
Alternate Names
Interferon gamma, IFNgamma, IFN gamma, IFN?, IFN-?, IFNg
Molecular Weight
20-25kDa
Chromosomal Location
12q14
Curated Database and Bioinformatic Data
Gene SymbolIFNG
Entrez Gene ID3458
Ensemble Gene IDENSG00000111537
RefSeq Protein Accession(s)NP_000610
RefSeq mRNA Accession(s)NM_000619
RefSeq Genomic Accession(s)NG_015840, NC_018923, NC_000012
UniProt ID(s)P01579
UniGene ID(s)P01579
HGNC ID(s)5438
Cosmic ID(s)IFNG
KEGG Gene ID(s)hsa:3458
PharmGKB ID(s)PA29674
General Description of Interferon gamma.
Recognizes a protein of 20-25kDa, identified as human interferon. This MAb is specific to human IFN-? and recognizes both recombinant and native human IFN-gamma. T lymphocytes and NK cells mainly produce IFN-?. It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses, including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. It has weak anti-viral and anti-proliferative activity, and potentiates the antiviral and anti-tumor effects of IFN-??? (type I interferon).

Human Anti-Interferon gamma Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Interferon gamma Antibody Clone: IFNG/466
Clone IFNG/466 Host and Isotype: Mouse IgG2b kappa
Anti-Human Interferon gamma Positive Control Sample: PMA stimulated human peripheral blood mononuclear cells. Renal or testicular carcinoma.
Cellular Localization of Antibody Cytoplasmic ;Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Purified recombinant human IFN-gamma
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Interferon gamma Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in Interferon gamma antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of Interferon gamma could be seen inadipocytes in mesenchymal tissue, cells in the endometrial stroma in endometrium, cells in the glomeruli in kidney, cells in the tubules in kidney, fibroblasts in skin, glandular cells in the adrenal gland, appendix, cervix, uterine, duodenum, epididymis, gallbladder, parathyroid gland, rectum, seminal vesicle, small intestine and stomach, keratinocytes in skin, Langerhans in skin, Leydig cells in the testis, macrophages in lung, melanocytes in skin, myocytes in heart muscle and skeletal muscle, neuronal cells in the hippocampus, non-germinal center cells in the tonsil, pneumocytes in lung, respiratory epithelial cells in the nasopharynx, smooth muscle cells in the smooth muscle, squamous epithelial cells in the oral mucosa and urothelial cells in the urinary bladder. We were unable to detect Interferon gamma in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Interferon gamma expression as measured by anti-Interferon gamma antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - + - - - - - - - - - - - - -
IFNG Variability ++ ++ + ++ ++ + ++ + ++ + ++ + ++ + ++ + + + ++ +

Limitations and Warranty

enQuire Bio's Interferon gamma Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Interferon gamma Antibody Clone IFNG/466

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