Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with KSP-Cadherin Monoclonal Antibody (SPM594)

Anti-Ksp-Cadherin / CDH16 Antibody Clone SPM594

$ 329.00
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SKU: 1014-MSM1X
Species: Human, Mouse, Rat, Rabbit, and Canine
Tested Applications: Flow Cytometry Immunofluorescence Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 1014-MSM1X-P1
Ksp-Cadherin / CDH16 General Information
Alternate Names
Cadherin-16, CDH16
Molecular Weight
130kDa
Chromosomal Location
16q22.1
Curated Database and Bioinformatic Data
Gene SymbolCDH16
Entrez Gene ID1014
Ensemble Gene IDENSG00000166589
RefSeq Protein Accession(s)NP_001191673, XP_005255827, NP_001191675, NP_004053, XP_011521109, NP_001191674
RefSeq mRNA Accession(s)NM_001204746, NM_004062, NM_001204745, XM_005255770, XM_011522807, NM_001204744
RefSeq Genomic Accession(s)NC_018927, NC_000016
UniProt ID(s)O75309
UniGene ID(s)O75309
HGNC ID(s)1755
Cosmic ID(s)CDH16
KEGG Gene ID(s)hsa:1014
PharmGKB ID(s)PA26289
General Description of Ksp-Cadherin / CDH16.
This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion, transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness, metastasis,, membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells, collecting duct cells,, not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.

Human, Mouse, Rat, Rabbit, and Canine Anti-Ksp-Cadherin / CDH16 Antibody Product Attributes

Species: Human, Mouse, Rat, Rabbit, and Canine
Tested Applications: Flow Cytometry Immunofluorescence Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml) Immunofluorescence (1-2ug of antibody/ml) Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-Ksp-Cadherin / CDH16 Antibody Clone: SPM594
Clone SPM594 Host and Isotype: Mouse IgG1 kappa
Anti-Human, Mouse, Rat, Rabbit, and Canine Ksp-Cadherin / CDH16 Positive Control Sample: Normal kidney or renal cell carcinoma.
Cellular Localization of Antibody Cell Surface with some cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human CDH16 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Ksp-Cadherin / CDH16 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in Ksp-Cadherin / CDH16 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the tubules in kidney and glandular cells in the thyroid gland. More moderate antibody staining intensity was present in cells in the tubules in kidney and glandular cells in the thyroid gland. Low, but measureable presence of Ksp-Cadherin / CDH16 could be seen in. We were unable to detect Ksp-Cadherin / CDH16 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Ksp-Cadherin / CDH16 expression as measured by anti-Ksp-Cadherin / CDH16 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - - - - - - - - - - - - - -
CDH16 Variability + + ++ + ++ + + + + + + + + + ++ + + + + +

Limitations and Warranty

enQuire Bio's Ksp-Cadherin / CDH16 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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