Antibody (Suitable for clinical applications)
Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
|Recommended Dilution (Conc)
||30 min at Room Temperature
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Anti-Laminin Antibody Clone: 4C7
Host and Isotype: Mouse IgG2a, kappa
Recommended Positive Control Sample: Skin
Cellular Localization of Antibody 4C7 Staining: Basement membrane
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Lot specific. Plese contact tech support
Immunogen: The A chain of human laminin.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.
Laminin Information for Pathologists
Major component on basement membrane, with type IV collagen. Trimeric glycoproteins (at least 11 types) with integrin binding site. Defects in laminin proteins cause skin blistering and myocardial diseases. Antibodies to laminin inhibit lung branching morphogenesis. Production of alpha-1 laminin by epithelial cells and mesenchymal cells depends on extent of mesenchymal and epithelial contact with each other; modulates mesenchymal cell shape.
Common Uses By Pathologists:
Double immunostaining with cytokeratin is useful to detect microinvasion in VIN or CIN (Arch Pathol Lab Med 2005;129:747).
Limitations and Warranty
This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.