Formalin-fixed, paraffin-embedded human Pituitary stained with LH alpha Monoclonal Antibody (LHa/756).
Formalin-fixed, paraffin-embedded human Pituitary stained with LH alpha Monoclonal Antibody (LHa/756).

Anti-LH, alpha Antibody Clone LHa/756

$ 129.00$ 459.00
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SKU: 1081-MSM2
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 1081-MSM2-P0
LH, alpha General Information
Alternate Names
Lipocalin-2, LCN2, neutrophil gelatinase-associated lipocalin, NGAL
Molecular Weight
13kDa
Chromosomal Location
6q12-q21
Curated Database and Bioinformatic Data
Gene SymbolLHA
Entrez Gene ID1081
Ensemble Gene IDENSG00000135346
RefSeq Protein Accession(s)NP_001239312, NP_000726
RefSeq mRNA Accession(s)NM_001252383, NM_000735
RefSeq Genomic Accession(s)NC_000006, NC_018917
UniProt ID(s)P01215, Q6I9S8, A0A087WYZ4
UniGene ID(s)P01215, Q6I9S8, A0A087WYZ4
HGNC ID(s)1885
Cosmic ID(s)CGA
KEGG Gene ID(s)hsa:1081
PharmGKB ID(s)PA26433
General Description of LH, alpha.
This MAb reacts with a protein of ~13kDa, identified as alpha sub-unit of Luteinizing Hormone (LH). Its structure is similar to the other glycoproteins, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two bridges. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. The beta subunits vary. LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor ;however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties. LH is synthesized and secreted by gonadotrophs in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle-stimulating hormone (FSH), it is necessary for proper reproductive function. In the female, an acute rise of LH levels triggers ovulation. In the male, where LH has also been called Interstitial Cell-Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

Human Anti-LH, alpha Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-LH, alpha Antibody Clone: LHa/756
Clone LHa/756 Host and Isotype: Mouse IgG1 kappa
Anti-Human LH, alpha Positive Control Sample: Anterior Pituitary
Cellular Localization of Antibody Cytoplasmic, secreted
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant full-length hLH alpha protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

LH, alpha Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's LH, alpha Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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