Anti-Lipocalin 2 / NGAL Antibody Clone LCN2-Q4

$ 248.00
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Species: Human
Tested Applications:
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
QDX5-100ug Size: 100 ug, Tag: Unconjugated
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SKU: QDX5-100ug
Lipocalin 2 / NGAL General Information
Alternate Names
25 kDa alpha-2-microglobulin-related subunit of MMP-9, Lipocalin-2, Oncogene 24p3, p25, LCN2, HNL,
Curated Database and Bioinformatic Data
Gene SymbolLCN2
Entrez Gene ID3934
Ensemble Gene IDENSG00000148346
RefSeq Protein Accession(s)NP_005555
RefSeq mRNA Accession(s)NM_005564
RefSeq Genomic Accession(s)NC_018920, NC_000009
UniProt ID(s)P80188
UniGene ID(s)P80188
HGNC ID(s)6526
Cosmic ID(s)LCN2
KEGG Gene ID(s)hsa:3934
PharmGKB ID(s)PA30309
General Description of Lipocalin 2 / NGAL.
Neutrophil gelatinase-associated lipocalin (NGAL) is a novel early marker of acute kidney injury (AKI) for which it has been shown that it can also be released from the injured myocardium. It is a small protein expressed in neutrophils and in low levels in the kidney, prostate, and epithelia of the respiratory and alimentary tracts.Under normal conditions NGAL levels are low in urine and plasma but rise sharply within 2 hours from basal levels in response to kidney injury to reach diagnostic levels within a very short time within 24 hours or more before any significant rise in serum creatinine. Because NGAL is protease resistant and small, the protein is easily excreted and detected in the urine. NGAL levels in patients with AKI have been associated with the severity of their prognosis and can be used as a biomarker for AKI. NGAL can also be used as an early diagnosis for procedures such aschronic kidney disease, contrast induced nephropathy, and kidney transplant.

Human Anti-Lipocalin 2 / NGAL Antibody Product Attributes

Species: Human
Tested Applications: .
Clonality: Monoclonal
Anti-Lipocalin 2 / NGAL Antibody Clone: LCN2-Q4
Clone LCN2-Q4 Host and Isotype: Mouse IgG1
Buffer and Stabilizer: PBS (pH 7.4)
Antibody Purification Method:Protein G
Storage Conditions: Upon receipt aliquot and store at -20C or -80C. Avoid repeated freeze.

Lipocalin 2 / NGAL Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in Lipocalin 2 / NGAL antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the cervix, uterine and hematopoietic cells in the bone marrow. More moderate antibody staining intensity was present in glandular cells in the cervix, uterine and hematopoietic cells in the bone marrow. Low, but measureable presence of Lipocalin 2 / NGAL could be seen inepidermal cells in the skin and glandular cells in the salivary gland. We were unable to detect Lipocalin 2 / NGAL in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Lipocalin 2 / NGAL expression as measured by anti-Lipocalin 2 / NGAL antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - ++ + ++ - + - + - - - ++ - - - + - - +
LCN2 Variability + + ++ ++ +++ + ++ ++ ++ + + ++ ++ + + ++ ++ + + ++

Limitations and Warranty

enQuire Bio's Anti-Human Lipocalin 2 / NGAL Antibody is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Lipocalin 2 / NGAL Antibody Clone LCN2-Q4