Formalin-fixed, paraffin-embedded human Tonsil stained with MALT1 Monoclonal Antibody (SPM578)
Formalin-fixed, paraffin-embedded human Tonsil stained with MALT1 Monoclonal Antibody (SPM578)

Anti-MALT1 Antibody Clone SPM578

$ 298.00
Please Select Product Options Below To View The Catalog Number.

SKU: 10892-MSM1X
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Western Blot
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 10892-MSM1X-P1
MALT1 General Information
Alternate Names
Mucosa-associated lymphoid tissue lymphoma translocation protein 1, MALT1
Molecular Weight
93kDa
Chromosomal Location
18q21.32
Curated Database and Bioinformatic Data
Gene SymbolMALT1
Entrez Gene ID10892
Ensemble Gene IDENSG00000172175
RefSeq Protein Accession(s)XP_011524096, NP_006776, NP_776216
RefSeq mRNA Accession(s)XR_001753135 NM_006785, XM_011525794, NM_173844, XR_001753134, XR_001753136
RefSeq Genomic Accession(s)NC_018929, NG_033893, NC_000018
UniProt ID(s)Q9UDY8, A8K5S1
UniGene ID(s)Q9UDY8, A8K5S1
HGNC ID(s)6819
Cosmic ID(s)MALT1
KEGG Gene ID(s)hsa:10892
PharmGKB ID(s)PA30568
General Description of MALT1.
Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains, fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21,, the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas, apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung, kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization, activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells, plasma cells.

Human Anti-MALT1 Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Western Blot.
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Western Blot (0.5-1ug of antibody/ml,Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-MALT1 Antibody Clone: SPM578
Clone SPM578 Host and Isotype: Mouse IgG1 kappa
Anti-Human MALT1 Positive Control Sample: Jurkat, Daudi or HeLa cells, or lymphoma.
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Human MALT1 recombinant fragment (aa701-808)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

MALT1 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-MALT1 antibody staining is expected to be primarily localized to the cytosol and nucleoli.

Observed Antibody Staining Data By Tissue Type:

Variations in MALT1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in germinal center cells in the lymph node, tonsil. More moderate antibody staining intensity was present in germinal center cells in the lymph node, tonsil. Low, but measureable presence of MALT1 could be seen indecidual cells in the placenta, glandular cells in the colon, duodenum, endometrium, epididymis, fallopian tube, gallbladder, parathyroid gland, prostate and stomach, lymphoid tissue in appendix, macrophages in lung, respiratory epithelial cells in the nasopharynx, squamous epithelial cells in the esophagus and urothelial cells in the urinary bladder. We were unable to detect MALT1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of MALT1 expression as measured by anti-MALT1 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - + - - + - - - + - + - - - -
MALT1 Variability ++ + ++ ++ ++ + ++ ++ ++ ++ + + + ++ + ++ + + + ++

Limitations and Warranty

enQuire Bio's MALT1 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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