Human Anti-MALT1 Antibody Product Attributes
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Western Blot.
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Western Blot (0.5-1ug of antibody/ml,Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-MALT1 Antibody Clone: SPM578
Clone SPM578 Host and Isotype: Mouse IgG1 kappa
Anti-Human MALT1 Positive Control Sample: Jurkat, Daudi or HeLa cells, or lymphoma.
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Human MALT1 recombinant fragment (aa701-808)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
MALT1 Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-MALT1 antibody staining is expected to be primarily localized to the cytosol and nucleoli.Observed Antibody Staining Data By Tissue Type:
Variations in MALT1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in germinal center cells in the lymph node, tonsil. More moderate antibody staining intensity was present in germinal center cells in the lymph node, tonsil. Low, but measureable presence of MALT1 could be seen indecidual cells in the placenta, glandular cells in the colon, duodenum, endometrium, epididymis, fallopian tube, gallbladder, parathyroid gland, prostate and stomach, lymphoid tissue in appendix, macrophages in lung, respiratory epithelial cells in the nasopharynx, squamous epithelial cells in the esophagus and urothelial cells in the urinary bladder. We were unable to detect MALT1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of MALT1 expression as measured by anti-MALT1 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | - | - | - | - | - | - | + | - | - | + | - | - | - | + | - | + | - | - | - | - |
| MALT1 Variability | ++ | + | ++ | ++ | ++ | + | ++ | ++ | ++ | ++ | + | + | + | ++ | + | ++ | + | + | + | ++ |
Limitations and Warranty
enQuire Bio's MALT1 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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