Human Anti-MAML2 Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-MAML2 Antibody Clone: MAML2/1302
Clone MAML2/1302 Host and Isotype: Mouse IgG2a
Anti-Human MAML2 Positive Control Sample: MCF-7 cells. Pancreas or Placenta. Bladder or Colon Carcinoma.
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length MAML2
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
MAML2 Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-MAML2 antibody staining is expected to be primarily localized to the nuclear bodies, nucleoplasm and cytosol. There is variability in either the signal strength or the localization of signal in nuclear bodies from cell to cell.Observed Antibody Staining Data By Tissue Type:
Variations in MAML2 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the endometrial stroma in endometrium, cells in the glomeruli in kidney, cells in the tubules in kidney, glandular cells in the adrenal gland, colon, duodenum, prostate, salivary gland and stomach, Leydig cells in the testis, macrophages in lung, Purkinje cells in the cerebellum, respiratory epithelial cells in the bronchus, squamous epithelial cells in the esophagus, oral mucosa and tonsil and urothelial cells in the urinary bladder. More moderate antibody staining intensity was present in cells in the endometrial stroma in endometrium, cells in the glomeruli in kidney, cells in the tubules in kidney, glandular cells in the adrenal gland, colon, duodenum, prostate, salivary gland and stomach, Leydig cells in the testis, macrophages in lung, Purkinje cells in the cerebellum, respiratory epithelial cells in the bronchus, squamous epithelial cells in the esophagus, oral mucosa and tonsil and urothelial cells in the urinary bladder. Low, but measureable presence of MAML2 could be seen inadipocytes in breast, cells in the granular layer in cerebellum, cells in the molecular layer in cerebellum, cells in the red pulp in spleen, cells in the white pulp in spleen, germinal center cells in the tonsil, glandular cells in the endometrium and epididymis, glial cells in the caudate nucleus, hematopoietic cells in the bone marrow, neuronal cells in the hippocampus and neuropil in cerebral cortex. We were unable to detect MAML2 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of MAML2 expression as measured by anti-MAML2 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | + | + | ++ | ++ | ++ | - | + | ++ | - | + | + | ++ | ++ | ++ | + | ++ | + | + | ++ | + |
| MAML2 Variability | ++ | ++ | ++ | ++ | ++ | ++ | ++ | +++ | ++ | ++ | ++ | + | +++ | ++ | +++ | ++ | ++ | ++ | ++ | ++ |
Limitations and Warranty
enQuire Bio's MAML2 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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