Immunohistochemical staining of Mast Cell Tryptase  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

Mast Cell Tryptase [AA1] Antibody (cGMP).

$ 135.00$ 675.00
Please Select Product Options Below To View The Catalog Number.

Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG1

Product NumberDescriptionPrice
QIVD297-0.1ml Size: 0.1 ml, Format: Concentrate $ 135.00
QIVD297-0.5ml Size: 0.5 ml, Format: Concentrate $ 415.00
QIVD297-1ml Size: 1 ml, Format: Concentrate $ 675.00
QIVD297-6ml Size: 6 ml, Format: Predilute $ 335.00
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Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

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Bioactivity (test results eg. IU/ml):

SKU: QIVD297-0.1ml
Mast Cell Tryptase General Information
Alternate Names
Molecular Weight
30.5 kDa
Chromosomal Location
p13.3 [chr: 16] [chr_start: 1240705] [chr_end: 1242554] [strand: 1]
Curated Database and Bioinformatic Data
Gene SymbolTPSAB1
Entrez Gene ID7177
RefSeq Protein Accession(s)NP_003285
RefSeq mRNA Accession(s)NM_003294
RefSeq Genomic Accession(s)NC_000016
UniProt ID(s)Q15661
PharmGKB ID(s)PA36698
KEGG Gene ID(s)hsa:7177
Associated Diseases (KEGG IDs)Hereditary alpha tryptasemia is caused by an increase in the copy number (usually between two and three copies) of the alpha allele. Affected individuals have elevated basal serum tryptase levels that are associated with cutaneous flushing and pruritus, dysautonomia, functional gastrointestinal symptoms, chronic pain, and connective tissue abnormalities. It is not clear if the associated multisystem complaints might be due to the coinheritance of a second functional genetic variant. {ECO:0000269|PubMed:27749843}.
General Description of Mast Cell Tryptase .
This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Mast cells contain a number of preformed chemicals mediators such as histamine, chymase, carboxypeptidase, and proteolytic tryptase. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:300-1:600
Pretreatment Citrate Buffer pH 6.0
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal
Anti-Mast Cell Tryptase Antibody Clone: AA1
Host and Isotype: Mouse IgG1
Recommended Positive Control Sample: Tonsil
Cellular Localization of Antibody AA1 Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: BALB/C mice were injected with a purified human lung tryptase.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Mast Cell Tryptase Information for Pathologists

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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Mast Cell Tryptase [AA1] Antibody (cGMP).