Human Anti-MMP2 / Collagenase Type IV A Antibody Product Attributes
Species: Human
Tested Applications: Western Blot.
Clonality: Monoclonal
Anti-MMP2 / Collagenase Type IV A Antibody Clone: MMP2/1501
Clone MMP2/1501 Host and Isotype: Mouse IgG1
Anti-Human MMP2 / Collagenase Type IV A Positive Control Sample: U-138 MG or U-87 MG cells. Placenta
Cellular Localization of Antibody <MMP2/1501 Staining: Cytoplasmic and Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human MMP2 protein fragment (aa444-575)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
MMP2 / Collagenase Type IV A Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in MMP2 / Collagenase Type IV A antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in endothelial cells in the cerebral cortex and colon and trophoblastic cells in the placenta. More moderate antibody staining intensity was present in endothelial cells in the cerebral cortex and colon and trophoblastic cells in the placenta. Low, but measureable presence of MMP2 / Collagenase Type IV A could be seen in cells in the endometrial stroma in endometrium, cells in the glomeruli in kidney, cells in the red pulp in spleen, glandular cells in the cervix, uterine, fallopian tube, parathyroid gland and prostate, Leydig cells in the testis, myocytes in heart muscle and smooth muscle cells in the smooth muscle. We were unable to detect MMP2 / Collagenase Type IV A in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of MMP2 / Collagenase Type IV A expression as measured by anti-MMP2 / Collagenase Type IV A antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | - | - | - | - | - | - | - | - | - | - | - | - | + | - | - | - | + | - | - | - |
| MMP2 Variability | + | + | + | + | + | + | ++ | ++ | ++ | + | + | ++ | ++ | ++ | ++ | + | ++ | + | ++ | ++ |
Limitations and Warranty
enQuire Bio's MMP2 / Collagenase Type IV A Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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