Antibody (Suitable for clinical applications)
Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
| Specification | Recommendation |
|---|---|
| Recommended Dilution (Conc) | 1:25-1:50 |
| Pretreatment | EDTA Buffer pH8.0 |
| Incubation Parameters | 60 min at Room Temperature |
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Clonality: Monoclonal
Anti-MSH6 Antibody Clone: 44
Host and Isotype: Mouse IgG1
Recommended Positive Control Sample: Tonsil, colon carcinoma
Cellular Localization of Antibody 44 Staining: Nuclear
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Human MSH6.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.
MSH6 Information for Pathologists
Summary:
The MSH6 gene on chromosome 2 is part of the DNA mismatch repair system. It encodes a component of the MutS family of proteins that are involved in DNA mismatch repair, and heterodimerizes with MSH2 to form the MutS alpha complex, which serves as a bidirectional molecular switch for the mismatch repair machinery. Essential features Mutations in MSH6 are associated with increased risk of colorectal cancer, hereditary nonpolyposis colon cancer, Lynch syndrome and endometrial cancer. Generally lead to milder microsatellite instability.Limitations and Warranty
This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.
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