Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC3 Monoclonal Antibody (MUC3/1154).

Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MUC3 Monoclonal Antibody (MUC3/1154).

Anti-MUC3 Antibody Clone MUC3/1154

Name: Anti-MUC3 Antibody Clone MUC3/1154
Brand: enQuire Bio
Price: 429 USD
Availability: InStock

$ 429.00

Please Select Product Options Below To View The Catalog Number.

SKU: 4584-MSM2
Species: Human and Rat (-)
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2a kappa
Mass Spec Validated?: Not MS Validated

Product Number	Description	Price
4584-MSM2-P1	Size: 100 ug, Tag: Unconjugated

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In Stock.

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Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: 4584-MSM2-P1

MUC3 General Information
Alternate Names
Mucin 3A, MUC3A
Molecular Weight
1100kDa
Chromosomal Location
7q22.1
Curated Database and Bioinformatic Data
Gene Symbol	MUC3A
Entrez Gene ID	4584, 57876
Ensemble Gene ID	ENSG00000169894
RefSeq Protein Accession(s)	XP_011514549, XP_011514551, XP_016867720, XP_011514552, XP_011514548, NP_005951
RefSeq mRNA Accession(s)	XM_011516246, XM_011516247, XM_011516250, XM_017012231, XM_011516249, NM_005960
RefSeq Genomic Accession(s)	NC_018918, NC_000007
UniProt ID(s)	Q9UN95, Q02505, Q9H3Q6
UniGene ID(s)	Q9UN95, Q02505, Q9H3Q6
HGNC ID(s)	7513, 13384
Cosmic ID(s)	MUC3A, MUC3B
KEGG Gene ID(s)	hsa:4584
General Description of MUC3.
It recognizes a protein of HMW, identified as mucin 3 glycoprotein (MUC3). This MAb shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC2. The Mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs) encoded by 60 base pairs (Mucin 1), 69 base pairs (Mucin 2), 51 base pairs (Mucin 3). The number of repeats is highly polymorphic, varies among different alleles. Mucin 1 proteins are expressed as type I membrane proteins in addition to secreted forms. Mucin 1 is aberrantly expressed in epithelial tumors including breast carcinomas. Mucin 2 coats the epithelia of the intestines, airways, is associated with colonic tumors. Mucin 3 is a major component of various mucus gels, is broadly expressed in normal, tumor cells.

Human and Rat (-) Anti-MUC3 Antibody Product Attributes

Species: Human and Rat (-)

Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).

Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)

Clonality: Monoclonal

Anti-MUC3 Antibody Clone: MUC3/1154

Clone MUC3/1154 Host and Isotype: Mouse IgG2a kappa

Anti-Human and Rat (-) MUC3 Positive Control Sample: LS174T cells or Gastric Carcinoma.

Cellular Localization of Antibody Cytoplasmic, cell surface

Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.

Antibody Concentration: 200ug/ml

Antibody Purification Method:Protein A/G Purified

Immunogen: A synthetic peptide of 35 amino acids, SIB35 (C-HSTPSFTSSITTTETTSHSTPSFTSSITTTETTS), which contains two of the MUC3 tandem repeats, coupled to KLH.

Storage Conditions: Store at 2 to 8Â° C (refrigerate). Stable for 24 months when properly stored.

MUC3 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of MUC3 expression as measured by anti-MUC3 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type	breast cancer	carcinoid	cervical cancer	colorectal cancer	endometrial cancer	glioma	head and neck cancer	liver cancer	lung cancer	lymphoma	melanoma	ovarian cancer	pancreatic cancer	prostate cancer	renal cancer	skin cancer	stomach cancer	testicular cancer	thyroid cancer	urothelial cancer
Signal Intensity	-	+	-	+	-	-	-	+	-	-	-	-	-	+	+	-	-	-	+	-
MUC3A Variability	+	+++	++	++	++	+	+	++	+	+	++	++	+	++	++	+	+	++	++	+

Limitations and Warranty

enQuire Bio's MUC3 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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