Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC5AC Monoclonal Antibody (SPM488).
Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC5AC Monoclonal Antibody (SPM488).

Anti-MUC5AC Antibody Clone SPM488

$ 298.00
Please Select Product Options Below To View The Catalog Number.

SKU: 4586-MSM5X
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
4586-MSM5X-P1 Size: 100 ug, Tag: Unconjugated
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In Stock.
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Datasheets and Documentation
Product Datasheet
SKU: 4586-MSM5X-P1
MUC5AC General Information
Alternate Names
Mucin 5AC, Muc5AC, MUC5AC
Molecular Weight
>1,000kDa
Chromosomal Location
11p15.5
Curated Database and Bioinformatic Data
Gene SymbolMUC5AC
Entrez Gene ID4586
Ensemble Gene IDENSG00000215182, ENSG00000283158
RefSeq Protein Accession(s)NP_001291288
RefSeq mRNA Accession(s)NM_017511, NM_001304359
RefSeq Genomic Accession(s)NW_015148966, NC_000011, NC_018922
UniProt ID(s)P98088, Q7M4S5
UniGene ID(s)P98088, Q7M4S5
HGNC ID(s)7515
Cosmic ID(s)MUC5AC
KEGG Gene ID(s)hsa:4586
PharmGKB ID(s)PA31321
General Description of MUC5AC.
Mucin 5AC glycoprotein (MUC5AC) is a HMW glycoprotein belonging to the superfamily of mucins. Mucins are produced by epithelial cells, can be divided into two families; secretory mucins, membrane bound mucins. MUC5AC is a mucus-forming, secreted mucin that is found in normal gastric, tracheo-bronchial mucosa, but absent from normal colon. MUC5AC expression is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma, pre-cancerous changes vs. normal pancreas.

Human Anti-MUC5AC Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (1-2ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-MUC5AC Antibody Clone: SPM488
Clone SPM488 Host and Isotype: Mouse IgG1 kappa
Anti-Human MUC5AC Positive Control Sample: Stomach
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: A synthetic peptide of human MUC5AC tandem repeat
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

MUC5AC Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in MUC5AC antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in respiratory epithelial cells in the bronchus, glandular cells in the cervix, uterine, respiratory epithelial cells in the nasopharynx and glandular cells in the stomach. More moderate antibody staining intensity was present in respiratory epithelial cells in the bronchus, glandular cells in the cervix, uterine, respiratory epithelial cells in the nasopharynx and glandular cells in the stomach. Low, but measureable presence of MUC5AC could be seen in. We were unable to detect MUC5AC in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's MUC5AC Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-MUC5AC Antibody Clone SPM488

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