Human Anti-NKX2.2 Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-NKX2.2 Antibody Clone: NX2/1523
Clone NX2/1523 Host and Isotype: Mouse IgG1 kappa
Anti-Human NKX2.2 Positive Control Sample: Pancreas or Ewing s sarcoma
Cellular Localization of Antibody Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Human recombinant NKX2.2 protein fragment (aa1-119)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
NKX2.2 Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in NKX2.2 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of NKX2.2 could be seen in cells in the molecular layer in cerebellum, glandular cells in the duodenum and epididymis, neuronal cells in the hippocampus, cells in the tubules in kidney, exocrine glandular cells in the pancreas, islets of Langerhans in pancreas, glandular cells in the seminal vesicle, epidermal cells in the skin, glandular cells in the small intestine and stomach, cells in the seminiferous ducts in testis, Leydig cells in the testis, non-germinal center cells in the tonsil and squamous epithelial cells in the tonsil. We were unable to detect NKX2.2 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of NKX2.2 expression as measured by anti-NKX2.2 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | ++ | + | - | + | + | + | - | - | - | - | - | - | - | ++ | + | - | + | - | - | - |
| NKX2-2 Variability | ++ | ++ | + | ++ | ++ | ++ | ++ | + | + | + | ++ | ++ | ++ | + | ++ | + | ++ | ++ | + | ++ |
Limitations and Warranty
enQuire Bio's NKX2.2 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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