Immunohistochemical staining of p40  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

p40 [Polyclonal] Antibody (cGMP).

$ 135.00$ 635.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD167
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Rabbit Undetermined

Product NumberDescriptionPrice
QIVD167-0.1ml Size: 0.1 ml, Format: Concentrate $ 135.00
QIVD167-0.5ml Size: 0.5ml, Format: Concentrate $ 395.00
QIVD167-1ml Size: 1 ml, Format: Concentrate $ 635.00
QIVD167-6ml Size: 6 ml, Format: Predilute $ 295.00
Shipping Information
In Stock
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QIVD167-0.1ml
p40 General Information
Alternate Names
Curated Database and Bioinformatic Data
UniProt ID(s)Q9H3D4-2
General Description of p40 .
p40 is a relatively unknown antibody that recognizes ΔNp63-a p63 isoform suggested to be highly specific for squamous/basal cells. In a recent study, p40 is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly superior to p63 in specificity1, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. These findings strongly support the routine use of p40 in place of p63 for the diagnosis of pulmonary squamous cell carcinoma.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:50-1:100
Pretreatment EDTA Buffer pH 8.0
Incubation Parameters 15 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Polyclonal
Anti-p40 Antibody Clone: Polyclonal
Host and Isotype: Rabbit Undetermined
Recommended Positive Control Sample: Prostate
Cellular Localization of Antibody Polyclonal Staining: Nuclear
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: A synthetic peptide corresponding to amino acids 5-17 of human p40.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

p40 Information for Pathologists

Summary:

One of 10 p63 isoforms (J Virol 2007;81:11569), important to classify non small cell lung cancer into adenocarcinoma (p40-) versus squamous cell carcinoma (p40+), which determines chemotherapy regimen. Truncated, nontransactivating isoform highly specific for squamous / basal cells. Terminology Also called ?Np63, p40. Different from these p40s:.

Notable Clinical Features:

Mutations cause ectrodactyly-ectodermal dysplasia-cleft syndrome, ankyloblepharon-ectodermal dysplasia-clefting syndrome, nonsyndromic split-hand/split-foot malformation (J Cell Sci 2011;124:2200). Uses by pathologists Classify non-small cell lung carcinoma on small biopsies or cell blocks:. Adenocarcinoma (?Np63- or Squamous cell carcinoma (?Np63+ [strong] and >50% of cells, TTF1-). Adenosquamous (?Np63 strong and less than 50%, J Thorac Oncol 2012;7:281, Am J Surg Pathol 2012;36:895).

Common Uses By Pathologists:

Classify non-small cell lung carcinoma on small biopsies or cell blocks:. Adenocarcinoma (?Np63- or Squamous cell carcinoma (?Np63+ [strong] and >50% of cells, TTF1-). Adenosquamous (?Np63 strong and less than 50%, J Thorac Oncol 2012;7:281, Am J Surg Pathol 2012;36:895). May help classify large cell lung carcinoma as part of panel (Am J Clin Pathol 2011;136:773). Microscopic (histologic) images

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

There are no reviews yet.

Be the first to review “p40 [Polyclonal] Antibody (cGMP).”

Your email address will not be published. Required fields are marked *

Share a Protocol (View Reviewed Protocols Below)

Protocol Title

Materials

Methods

Notes


  protocol submission gif
enQuire Bio, LLC   8420 S Continental Divide Rd, #202   Littleton, CO 80127
Phone: 1-855-344-1400 | enquire@enquirebio.com | Fax: 1-720-897-3730
Customer Service Available M-F 8AM-6PM MST or 24/7 Via Email

p40 [Polyclonal] Antibody (cGMP).