Antibody (Suitable for clinical applications)
Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
|Recommended Dilution (Conc)
||EDTA Buffer pH 8.0
||15 min at Room Temperature
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Anti-p40 Antibody Clone: Polyclonal
Host and Isotype: Rabbit Undetermined
Recommended Positive Control Sample: Prostate
Cellular Localization of Antibody Polyclonal Staining: Nuclear
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Lot specific. Plese contact tech support
Immunogen: A synthetic peptide corresponding to amino acids 5-17 of human p40.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.
p40 Information for Pathologists
One of 10 p63 isoforms (J Virol 2007;81:11569), important to classify non small cell lung cancer into adenocarcinoma (p40-) versus squamous cell carcinoma (p40+), which determines chemotherapy regimen. Truncated, nontransactivating isoform highly specific for squamous / basal cells. Terminology Also called ?Np63, p40. Different from these p40s:.
Notable Clinical Features:
Mutations cause ectrodactyly-ectodermal dysplasia-cleft syndrome, ankyloblepharon-ectodermal dysplasia-clefting syndrome, nonsyndromic split-hand/split-foot malformation (J Cell Sci 2011;124:2200). Uses by pathologists Classify non-small cell lung carcinoma on small biopsies or cell blocks:. Adenocarcinoma (?Np63- or Squamous cell carcinoma (?Np63+ [strong] and >50% of cells, TTF1-). Adenosquamous (?Np63 strong and less than 50%, J Thorac Oncol 2012;7:281, Am J Surg Pathol 2012;36:895).
Common Uses By Pathologists:
Classify non-small cell lung carcinoma on small biopsies or cell blocks:. Adenocarcinoma (?Np63- or Squamous cell carcinoma (?Np63+ [strong] and >50% of cells, TTF1-). Adenosquamous (?Np63 strong and less than 50%, J Thorac Oncol 2012;7:281, Am J Surg Pathol 2012;36:895). May help classify large cell lung carcinoma as part of panel (Am J Clin Pathol 2011;136:773). Microscopic (histologic) images
Limitations and Warranty
This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.