FFPE human renal cell carcinoma sections stained with 100 ul anti-PAX8 (clone PAX8/1491) at 1:300. HIER epitope retrieval prior to staining was performed in 10mM Citrate, pH 6.0.Formalin-fixed, paraffin embedded human thyroidal carcinoma sections stained with 100 ul anti-PAX8 (clone PAX8/1491) at 1:300. HIER epitope retrieval prior to staining was performed in 10mM Citrate, pH 6.0.Western Blot Analysis (A) Recombinant Protein (B) Raji Cell Lysate Using PAX8 Monoclonal Antibody (PAX8/1491).

Anti-PAX8 Antibody Clone PAX8/1491

$ 199.00$ 459.00
Please Select Product Options Below To View The Catalog Number.

SKU: 7849-MSM1
Species: Human
Tested Applications: Western Blot
Available Conjugates: Unconjugated
Isotype: Mouse IgG2b
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
7849-MSM1-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
7849-MSM1-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
7849-MSM1-P2 Size: 200 ug, Tag: Unconjugated $ 459.00
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SKU: 7849-MSM1-P0
PAX8 General Information
Alternate Names
Paired box gene 8, PAX8
Molecular Weight
62kDa
Chromosomal Location
2q13
Curated Database and Bioinformatic Data
Gene SymbolPAX8
Entrez Gene ID7849
Ensemble Gene IDENSG00000125618
RefSeq Protein Accession(s)NP_003457, NP_039246, XP_011510093, XP_011510096, XP_011510094, XP_011510095, XP_016860368, NP_039247, XP_011510092, NP_054698, XP_016860367
RefSeq mRNA Accession(s)NM_013951, XM_017004878, XM_011511790, XR_923021, XM_011511793, NM_013992 NM_013953, XM_011511791, XM_011511792, XM_017004879, XM_011511794, NM_003466, NM_013952
RefSeq Genomic Accession(s)NC_018913, NG_012384, NC_000002
UniProt ID(s)R9W7C9, A0A024R4X8, A0A024R531, A0A024R524, Q06710
UniGene ID(s)R9W7C9, A0A024R4X8, A0A024R531, A0A024R524, Q06710
HGNC ID(s)8622
Cosmic ID(s)PAX8
KEGG Gene ID(s)hsa:7849
PharmGKB ID(s)PA32962
General Description of PAX8.
Recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.

Human Anti-PAX8 Antibody Product Attributes

Species: Human
Tested Applications: Western Blot.
Clonality: Monoclonal
Anti-PAX8 Antibody Clone: PAX8/1491
Clone PAX8/1491 Host and Isotype: Mouse IgG2b
Anti-Human PAX8 Positive Control Sample: Raji cells. Renal Cell Carcinoma (RCC)
Cellular Localization of Antibody Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human PAX8 fragment (aa60-261)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

PAX8 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-PAX8 antibody staining is expected to be primarily localized to the nucleoplasm.

Limitations and Warranty

enQuire Bio's PAX8 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-PAX8 Antibody Clone PAX8/1491

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