Formalin-fixed, paraffin-embedded human Tonsil stained with PD1 (CD279) MAb (PDCD1/922).
Formalin-fixed, paraffin-embedded human Tonsil stained with PD1 (CD279) MAb (PDCD1/922).

Anti-PD1 / PDCD1 / CD279 Antibody Clone PDCD1/922

$ 298.00
Please Select Product Options Below To View The Catalog Number.

SKU: 5133-MSM1
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
5133-MSM1-P1 Size: 100 ug, Tag: Unconjugated
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SKU: 5133-MSM1-P1
PD1 / PDCD1 / CD279 General Information
Alternate Names
Programmed cell death protein 1, PD-1, PDCD-1, PD1, CD279, cluster of differentiation 279
Molecular Weight
55kDa
Chromosomal Location
2q37.3
Curated Database and Bioinformatic Data
Gene SymbolPDCD1
Entrez Gene ID5133
Ensemble Gene IDENSG00000276977, ENSG00000188389
RefSeq Protein Accession(s)NP_005009, XP_006712636, XP_016859782
RefSeq mRNA Accession(s)NM_005018, XM_006712573, XM_017004293
RefSeq Genomic Accession(s)NG_187527, NC_018913, NC_000002, NG_012110
UniProt ID(s)Q15116, A0A0M3M0G7
UniGene ID(s)Q15116, A0A0M3M0G7
HGNC ID(s)8760
Cosmic ID(s)PDCD1
KEGG Gene ID(s)hsa:5133
PharmGKB ID(s)PA33110
General Description of PD1 / PDCD1 / CD279.
PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor, a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells,, myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma, suggests a unique cell of origin for this neoplasm. Unlike CD10, BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific, useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.

Human Anti-PD1 / PDCD1 / CD279 Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-PD1 / PDCD1 / CD279 Antibody Clone: PDCD1/922
Clone PDCD1/922 Host and Isotype: Mouse IgG1 kappa
Anti-Human PD1 / PDCD1 / CD279 Positive Control Sample: TY cells or Tonsil.
Cellular Localization of Antibody Cell Surface & Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant full-length human PDCD1 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

PD1 / PDCD1 / CD279 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in PD1 / PDCD1 / CD279 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in germinal center cells in the tonsil. More moderate antibody staining intensity was present in germinal center cells in the tonsil. Low, but measureable presence of PD1 / PDCD1 / CD279 could be seen in cells in the red pulp in spleen. We were unable to detect PD1 / PDCD1 / CD279 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's PD1 / PDCD1 / CD279 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-PD1 / PDCD1 / CD279 Antibody Clone PDCD1/922

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