Human Anti-Progesterone Receptor Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Application Notes: Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 min at RT)
Clonality: Monoclonal
Anti-Progesterone Receptor Antibody Clone: PR484
Clone PR484 Host and Isotype: Mouse IgG1 kappa
Anti-Human Progesterone Receptor Positive Control Sample: T47-D Cells or Breast Cancers.
Cellular Localization of Antibody Nucleus
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human Progesterone Receptor protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
Progesterone Receptor Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in Progesterone Receptor antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the cervix, uterine and endometrium, cells in the endometrial stroma in endometrium, glandular cells in the fallopian tube and smooth muscle cells in the smooth muscle. More moderate antibody staining intensity was present in glandular cells in the cervix, uterine and endometrium, cells in the endometrial stroma in endometrium, glandular cells in the fallopian tube and smooth muscle cells in the smooth muscle. Low, but measureable presence of Progesterone Receptor could be seen in. We were unable to detect Progesterone Receptor in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of Progesterone Receptor expression as measured by anti-Progesterone Receptor antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | - | - | - | - | ++ | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| PGR Variability | ++ | ++ | + | + | +++ | + | ++ | + | + | + | + | + | + | + | + | + | + | + | + | + |
Limitations and Warranty
enQuire Bio's Progesterone Receptor Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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