Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with Progesterone Receptor Ab (PR484).
Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with Progesterone Receptor Ab (PR484).

Anti-Progesterone Receptor Antibody Clone PR484

$ 298.00
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SKU: 5241-MSM1
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
5241-MSM1-P1 Size: 100 ug, Tag: Unconjugated
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SKU: 5241-MSM1-P1
Progesterone Receptor General Information
Alternate Names
Progesterone Receptor, Anti-Progesterone Receptor antibody, anti-PGR antibody, PGR
Molecular Weight
PR-A (81kDa), PR-B (116kDa).
Chromosomal Location
11q22.1
Curated Database and Bioinformatic Data
Gene SymbolPGR
Entrez Gene ID5241
Ensemble Gene IDENSG00000082175
RefSeq Protein Accession(s)NP_001258091, XP_006718921, NP_001258090, XP_011541171, NP_000917, NP_001189403
RefSeq mRNA Accession(s)XM_006718858, XM_011542869, NM_001202474, NR_073143 NM_001271162, NR_073141, NR_073142, NM_001271161, NM_000926
RefSeq Genomic Accession(s)NG_016475, NC_018922, NC_000011
UniProt ID(s)P06401
UniGene ID(s)P06401
HGNC ID(s)8910
Cosmic ID(s)PGR
KEGG Gene ID(s)hsa:5241
PharmGKB ID(s)PA266
General Description of Progesterone Receptor.
This MAb is specific to progesterone receptor, shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81kDa), PR-B (116kDa). Expression of PgR has been suggested to reflect a intact estrogen regulatory machinery, therefore, predict better clinical response to endocrine therapy than ER alone. It is excellent for immunohistochemical staining of formalin/paraffin tissues.

Human Anti-Progesterone Receptor Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Application Notes: Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 min at RT)
Clonality: Monoclonal
Anti-Progesterone Receptor Antibody Clone: PR484
Clone PR484 Host and Isotype: Mouse IgG1 kappa
Anti-Human Progesterone Receptor Positive Control Sample: T47-D Cells or Breast Cancers.
Cellular Localization of Antibody Nucleus
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human Progesterone Receptor protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Progesterone Receptor Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in Progesterone Receptor antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the cervix, uterine and endometrium, cells in the endometrial stroma in endometrium, glandular cells in the fallopian tube and smooth muscle cells in the smooth muscle. More moderate antibody staining intensity was present in glandular cells in the cervix, uterine and endometrium, cells in the endometrial stroma in endometrium, glandular cells in the fallopian tube and smooth muscle cells in the smooth muscle. Low, but measureable presence of Progesterone Receptor could be seen in. We were unable to detect Progesterone Receptor in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Progesterone Receptor expression as measured by anti-Progesterone Receptor antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - ++ - - - - - - - - - - - - - - -
PGR Variability ++ ++ + + +++ + ++ + + + + + + + + + + + + +

Limitations and Warranty

enQuire Bio's Progesterone Receptor Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Progesterone Receptor Antibody Clone PR484

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