Antibody (Suitable for clinical applications)
Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
|Recommended Dilution (Conc)||1:50-1:100|
|Pretreatment||Citrate Buffer pH 6.0|
|Incubation Parameters||30 min at Room Temperature|
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Anti-Prostate Specific Antigen Antibody Clone: EP109
Host and Isotype: Rabbit Rabbit IgG
Recommended Positive Control Sample: Prostate
Cellular Localization of Antibody EP109 Staining: Cytoplasm
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: A synthetic peptide corresponding to residues near the C-terminus ofhuman PSA protein
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.
Prostate Specific Antigen Information for Pathologists
Summary:Kallikrein related serine protease produced by secretory epithelium, drains into ductal system. Cleaves and liquefies seminal coagulum formed after ejaculation. Clinical features Serum PSA > 4 seen in 80% with histologically documented cancer but also in 25 - 30% with nodular hyperplasia, prostatitis, infarcts, prostatic massage, cystoscopy. Elevated in 2 of 18 post-race marathon runners (Arch Pathol Lab Med 2003;127:345).
Common Uses By Pathologists:Glycoprotein detected in benign and malignant prostate tissue. Identifies prostatic origin of most metastatic tumors, differentiates between prostatic and urothelial carcinomas. Non-prostate tumors are usually weak / negative for PSA / PAP. PSA is more sensitive (intense, diffuse staining) and specific than PAP. Microscopic (histologic) images
Limitations and Warranty
This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.
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