Immunohistochemical staining of Prostatic Acid Phosphatase  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

Prostatic Acid Phosphatase [PASE/4LJ] Antibody (cGMP).

$ 135.00$ 405.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD181
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG1, kappa

Product NumberDescriptionPrice
QIVD181-0.1ml Size: 0.1 ml, Format: Concentrate $ 135.00
QIVD181-0.5ml Size: 0.5 ml, Format: Concentrate $ 245.00
QIVD181-1ml Size: 1 ml, Format: Concentrate $ 405.00
QIVD181-6ml Size: 6 ml, Format: Predilute $ 245.00
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Datasheets and Documentation
Product Datasheet
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SKU: QIVD181-0.1ml
Prostatic Acid Phosphatase General Information
Alternate Names
Molecular Weight
44.6 kDa
Chromosomal Location
q22.1 [chr: 3] [chr_start: 132317369] [chr_end: 132368298] [strand: 1]
Curated Database and Bioinformatic Data
Gene SymbolACPP
Entrez Gene ID55
RefSeq Protein Accession(s)NP_001090; NP_001127666; NP_001278966
RefSeq mRNA Accession(s)XM_011512946; NM_001134194; XM_011512947; NM_001292037; NM_001099
RefSeq Genomic Accession(s)NC_000003; NG_047032
UniProt ID(s)P15309
PharmGKB ID(s)PA24449
KEGG Gene ID(s)hsa:55
General Description of Prostatic Acid Phosphatase .
This antibody is specific to human prostatic acid phosphatase. It reacts with the glandular epithelium of normal and hyperplastic prostate and with prostate adenocarcinoma.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:25-1:100
Pretreatment No Pretreatment Required
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal
Anti-Prostatic Acid Phosphatase Antibody Clone: PASE/4LJ
Host and Isotype: Mouse IgG1, kappa
Recommended Positive Control Sample: Prostate carcinoma
Cellular Localization of Antibody PASE/4LJ Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: BALB/C mice were injected with purified prostatic acid phosphatase from human seminal plasma.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Prostatic Acid Phosphatase Information for Pathologists

Summary:

Prostatic acid phosphatase (PAP), also prostatic specific acid phosphatase (PSAP), is enzyme produced by prostate tissue. Acid phosphatases release phosphate groups, optimally at acid pH. May promote HIV infection. Naturally occurring fragments form amyloid fibrils (Semen-derived Enhancer of Virus Infection), capture HIV virions and promote their attachment to target cells (Cell 2007;131:1059). Uses by pathologists

Common Uses By Pathologists:

Identifies prostatic origin of metastases (whose primary is PAP+), including bone metastases (Ann NY Acad Sci 2011;1237). Differentiates between prostatic and urothelial carcinomas. Differentiates between prostatic adenocarcinoma and mesonephric remnant hyperplasia (Ann Diagn Pathol 2009;13:402). Presence is presumptive test for semen in forensic studies. Microscopic (histologic) images

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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Prostatic Acid Phosphatase [PASE/4LJ] Antibody (cGMP).