Antibody (Suitable for clinical applications)
Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
| Specification | Recommendation |
|---|---|
| Recommended Dilution (Conc) | 1:25-1:100 |
| Pretreatment | No Pretreatment Required |
| Incubation Parameters | 30 min at Room Temperature |
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Clonality: Monoclonal
Anti-Prostatic Acid Phosphatase Antibody Clone: PASE/4LJ
Host and Isotype: Mouse IgG1, kappa
Recommended Positive Control Sample: Prostate carcinoma
Cellular Localization of Antibody PASE/4LJ Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: BALB/C mice were injected with purified prostatic acid phosphatase from human seminal plasma.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.
Prostatic Acid Phosphatase Information for Pathologists
Summary:
Prostatic acid phosphatase (PAP), also prostatic specific acid phosphatase (PSAP), is enzyme produced by prostate tissue. Acid phosphatases release phosphate groups, optimally at acid pH. May promote HIV infection. Naturally occurring fragments form amyloid fibrils (Semen-derived Enhancer of Virus Infection), capture HIV virions and promote their attachment to target cells (Cell 2007;131:1059). Uses by pathologistsCommon Uses By Pathologists:
Identifies prostatic origin of metastases (whose primary is PAP+), including bone metastases (Ann NY Acad Sci 2011;1237). Differentiates between prostatic and urothelial carcinomas. Differentiates between prostatic adenocarcinoma and mesonephric remnant hyperplasia (Ann Diagn Pathol 2009;13:402). Presence is presumptive test for semen in forensic studies. Microscopic (histologic) imagesLimitations and Warranty
This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.
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