Formalin-fixed, paraffin-embedded Human Bladder Carcinoma stained with Protocadherin FAT2 Monoclonal Antibody (8C5).
Formalin-fixed, paraffin-embedded Human Bladder Carcinoma stained with Protocadherin FAT2 Monoclonal Antibody (8C5).

Anti-Protocadherin FAT2 Antibody Clone 8C5

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 2196-MSM1
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 2196-MSM1-P0
Protocadherin FAT2 General Information
Alternate Names
FAT2, FAT atypical cadherin 2
Molecular Weight
480kDa
Chromosomal Location
5q33.1
Curated Database and Bioinformatic Data
Gene SymbolFAT2
Entrez Gene ID2196
Ensemble Gene IDENSG00000086570
RefSeq Protein Accession(s)XP_011535905, XP_006714824, XP_016864714, XP_016864715, XP_016864716, NP_001438, XP_011535902, XP_016864713
RefSeq mRNA Accession(s)XM_006714761, XM_011537603, XM_017009227, XM_017009224, XM_017009225, XR_001742039, XR_001742040, NM_001447, XM_011537600
RefSeq Genomic Accession(s)NG_046979, NC_000005, NC_018916
UniProt ID(s)Q9NYQ8, Q6PIA2
UniGene ID(s)Q9NYQ8, Q6PIA2
HGNC ID(s)3596
Cosmic ID(s)FAT2
KEGG Gene ID(s)hsa:2196
PharmGKB ID(s)PA28009
General Description of Protocadherin FAT2.
Recognizes a protein of 480kDa, which is identified as FAT2. The cadherins represent a family of Ca2+-dependent adhesion molecules that function to mediate cell-to-cell binding that is critical for the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short C-terminal intracellular domain interacts with a variety of cytoplasmic proteins, including ?-catenin, to regulate cadherin function. The cadherin superfamily includes cadherins, protocadherins, desmogleins and desmocollins. FAT2 (FAT tumor suppressor homolog 2) is a single-pass type I membrane protein that belongs to the protocadherin subfamily of cadherins. FAT2 contains one Laminin G-like domain, two EGF-like domains and 32 cadherin domains and is believed to function as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development.

Human Anti-Protocadherin FAT2 Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Protocadherin FAT2 Antibody Clone: 8C5
Clone 8C5 Host and Isotype: Mouse IgG1 kappa
Anti-Human Protocadherin FAT2 Positive Control Sample: Esophagus, Cervix, Uterus, Tonsil or Cerebellum.
Cellular Localization of Antibody Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Purified recombinant human FAT2 fusion protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Protocadherin FAT2 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in Protocadherin FAT2 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the granular layer in cerebellum, epidermal cells in the skin, squamous epithelial cells in the cervix and uterine, tonsil and vagina. More moderate antibody staining intensity was present in cells in the granular layer in cerebellum, epidermal cells in the skin, squamous epithelial cells in the cervix and uterine, tonsil and vagina. Low, but measureable presence of Protocadherin FAT2 could be seen inkeratinocytes in skin. We were unable to detect Protocadherin FAT2 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Protocadherin FAT2 expression as measured by anti-Protocadherin FAT2 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - - - - - - - - - - - - - +
FAT2 Variability + + + + + + + + + + + + + + + + + + + ++

Limitations and Warranty

enQuire Bio's Protocadherin FAT2 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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