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Anti-Retinol-Binding Protein 4 Antibody Clone RBP4-Q9

$ 399.00
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SKU: QDX9
Species: Human
Tested Applications: ELISA,
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: QDX9-100ug
Retinol-Binding Protein 4 General Information
Alternate Names
RBP4
Curated Database and Bioinformatic Data
Gene SymbolRBP4
Entrez Gene ID5950
Ensemble Gene IDENSG00000138207
RefSeq Protein Accession(s)NP_001310446, NP_001310447, NP_006735
RefSeq mRNA Accession(s)NM_001323517, NM_001323518, NM_006744,
RefSeq Genomic Accession(s)NC_000010, NC_018921, NG_009104
UniProt ID(s)Q5VY30, P02753
UniGene ID(s)Q5VY30, P02753
HGNC ID(s)9922
Cosmic ID(s)RBP4
KEGG Gene ID(s)hsa:5950
PharmGKB ID(s)PA34289
General Description of Retinol-Binding Protein 4.
Retinol Binding Protein 4 (RBP4) belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. Retinol-binding protein 4 has recently been described as an adipokine that contributes to insulin resistance in the AG4KO mouse model. It is secreted by adipocytes, and can act as a signal to other cells, when there is a decrease in plasma glucose concentration.Mutations in the RBP4 gene have recently been linked to a form of autosomal dominant microphthalmia, anophthalmia, and coloboma (MAC) disease.

Human Anti-Retinol-Binding Protein 4 Antibody Product Attributes

Species: Human
Tested Applications: ELISA,.
Clonality: Monoclonal
Anti-Retinol-Binding Protein 4 Antibody Clone: RBP4-Q9
Clone RBP4-Q9 Host and Isotype: Mouse IgG1
Buffer and Stabilizer: PBS (pH 7.4)
Antibody Purification Method:Protein G
Storage Conditions: Upon receipt aliquot and store at -20C or -80C. Avoid repeated freeze.

Retinol-Binding Protein 4 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in Retinol-Binding Protein 4 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the tubules in kidney, hepatocytes in liver and islets of Langerhans in pancreas. More moderate antibody staining intensity was present in cells in the tubules in kidney, hepatocytes in liver and islets of Langerhans in pancreas. Low, but measureable presence of Retinol-Binding Protein 4 could be seen inglandular cells in the breast, peripheral nerve/ganglion in colon, glandular cells in the duodenum, decidual cells in the placenta, cells in the seminiferous ducts in testis and Leydig cells in the testis. We were unable to detect Retinol-Binding Protein 4 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Retinol-Binding Protein 4 expression as measured by anti-Retinol-Binding Protein 4 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity + + - + + - - +++ - + - + - + ++ - + + + +
RBP4 Variability + ++ + ++ ++ + ++ ++ ++ ++ + ++ ++ + ++ ++ ++ ++ + ++

Limitations and Warranty

enQuire Bio's Anti-Human Retinol-Binding Protein 4 Antibody is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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