Immunohistochemical staining of S-100 Beta  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

S-100 Beta [EP32] Antibody (cGMP).

$ 158.00$ 838.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD189
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Rabbit Rabbit IgG

Product NumberDescriptionPrice
QIVD189-0.1ml Size: 0.1 ml, Format: Concentrate $ 158.00
QIVD189-0.5ml Size: 0.5 ml, Format: Concentrate $ 528.00
QIVD189-1ml Size: 1 ml, Format: Concentrate $ 838.00
QIVD189-6ml Size: 6 ml, Format: Predilute $ 398.00
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Datasheets and Documentation
Product Datasheet
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SKU: QIVD189-0.1ml
S-100 Beta General Information
Alternate Names
Molecular Weight
10.7 kDa
Chromosomal Location
q22.3 [chr: 21] [chr_start: 46598604] [chr_end: 46605208] [strand: -1]
Curated Database and Bioinformatic Data
Gene SymbolS100B
Entrez Gene ID6285
RefSeq Protein Accession(s)XP_016883913; NP_006263
RefSeq mRNA Accession(s)XM_017028424; NM_006272
RefSeq Genomic Accession(s)NC_000021
UniProt ID(s)P04271
PharmGKB ID(s)PA34912
KEGG Gene ID(s)hsa:6285
General Description of S-100 Beta .
S100 Beta is a homodimeric member of the S100 superfamily. S100 is a family of Ca2+-binding proteins, comprises 19 members that are differentially expressed in a large number of cell types. The protein has been implicated in cellular processes such as cell differentiation and growth. S100 Beta is abundant in glial cells of the central and peripheral nervous system, in melanocytes, chondrocytes, and adipocytes. Antibody to S100 Beta also labels Langerhans cells, histiocytes, epithelial, myoepithelial cells and integrating reticular cells of lymphoid tissue, and tumors originated from these cells. S100 Beta is a useful marker for diagnosis of melanoma, tumors of nervous system.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:50-1:100
Pretreatment Citrate Buffer pH 6.0
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal
Anti-S-100 Beta Antibody Clone: EP32
Host and Isotype: Rabbit Rabbit IgG
Recommended Positive Control Sample: Skin Melanoma
Cellular Localization of Antibody EP32 Staining: Cytoplasm
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: A synthetic peptide corresponding to residues on the C-terminus of humanS100 Beta protein
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

S-100 Beta Information for Pathologists

Summary:

S100B may be important in a variety of cellular processes including stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, and inhibition of microtubule assembly. It plays a role in proliferation of melanoma cells, neurite extension, astrocytosis and axonal proliferation. S100B is glial-specific and is expressed primarily by astrocytes, but not all astrocytes express S100B. It has been shown that S100B is only expressed by a subtype of mature astrocytes that ensheath blood vessels and by NG2-expressing cells.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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S-100 Beta [EP32] Antibody (cGMP).