Immunohistochemical staining of S-100  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

S-100 [SH-B1] Antibody (cGMP).

$ 168.00$ 568.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD185
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG1

Product NumberDescriptionPrice
QIVD185-0.1ml Size: 0.1 ml, Format: Concentrate $ 168.00
QIVD185-0.5ml Size: 0.5 ml, Format: Concentrate $ 348.00
QIVD185-1ml Size: 1 ml, Format: Concentrate $ 568.00
QIVD185-6ml Size: 6 ml, Format: Predilute $ 448.00
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Datasheets and Documentation
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SKU: QIVD185-0.1ml
S-100 General Information
Alternate Names
Curated Database and Bioinformatic Data
UniProt ID(s)Multiple
General Description of S-100 .
This antibody is specific against an epitope located on the beta chain (i.e. in S-100a and S-100b) but not on the alpha chain of S-100 (i.e. in S-100a and S-100ao). This antibody can be used to localize S-100a and S-100b in various tissue sections.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:50-1:100
Pretreatment HistoZyme
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal
Anti-S-100 Antibody Clone: SH-B1
Host and Isotype: Mouse IgG1
Recommended Positive Control Sample: Melanoma
Cellular Localization of Antibody SH-B1 Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Purified bovine brain S-100beta preparation.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

S-100 Information for Pathologists

Summary:

Acidic protein, 100% Soluble in ammonium sulfate at neutral pH (derivation of name). S100 protein family is multigenic group of nonubiquitous cytoplasmic EF-hand Ca2+-binding proteins, sharing significant structural similarities at both genomic and protein levels; S100 protein family has 24 known human members each coded by a separate gene; at least 19 on chromosome 1q21 (Hepat Mon 2012;12:e7240). Helps regulate cell contraction, motility, growth, differentiation, cell cycle progression, transcription and secretion. Structurally similar to calmodulin. Interpretation

Common Uses By Pathologists:

Common marker of neural tissue / lesions and melanoma. Differentiate plexiform schwannoma (S100+, Am J Surg Pathol 2005;29:1042) from MPNST (weak / negative / patchy). MelanA and MART1 appear to be superior to S100 for evaluating sentinel lymph nodes for melanoma (Am J Surg Pathol 2001;25:1039). Microscopic (histologic) images Images hosted on PathOut server:.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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S-100 [SH-B1] Antibody (cGMP).