Antibody (Suitable for clinical applications)
Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
| Specification | Recommendation |
|---|---|
| Recommended Dilution (Conc) | 1:100-1:500 |
| Pretreatment | Citrate Buffer pH 6.0 |
| Incubation Parameters | 30 min at Room Temperature |
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Clonality: Monoclonal
Anti-Smooth Muscle Myosin Antibody Clone: SMMS-1
Host and Isotype: Mouse IgG1
Recommended Positive Control Sample: Colon, appendix
Cellular Localization of Antibody SMMS-1 Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Human uterus smooth muscle extract
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.
Smooth Muscle Myosin Information for Pathologists
Summary:
Smooth Muscle Myosin (heavy chain, also known as SMMHC) is encoded by the MYH11 gene. Fusion between core binding factor beta (CBF-beta) with SMMHC (CBFbeta-SMMHC; Inv(16)(p13q22)) is present in nearly all acute myeloid leukemia M4 eosinophilia subtype (AML M4Eo). Smooth Muscle Myosin is useful for differentiating between benign and malignant lesions.Common Uses By Pathologists:
SMM is present in acute myeloid leukemia of M4 eosinophilia subtype. SMM IHC staining can be used to evaluate restenosis in peripheral artery disease. Its expression is decreased in diverticular disease.Limitations and Warranty
This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.
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