Formalin-fixed, paraffin-embedded human Leiomyosarcoma stained with SM-MHC Monoclonal Antibody (MYH11/923).
Formalin-fixed, paraffin-embedded human Leiomyosarcoma stained with SM-MHC Monoclonal Antibody (MYH11/923).Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with SM-MHC Monoclonal Antibody (MYH11/923).Formalin-fixed, paraffin-embedded human Angiosarcoma stained with SM-MHC Monoclonal Antibody (MYH11/923).

Anti-Smooth Muscle Myosin Heavy Chain Antibody Clone MYH11/923

$ 298.00
Please Select Product Options Below To View The Catalog Number.

SKU: 4629-MSM3
Species: Human, Rat, and Broad Species Reactivity
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
4629-MSM3-P1 Size: 100 ug, Tag: Unconjugated
Shipping Information
In Stock.
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: 4629-MSM3-P1
Smooth Muscle Myosin Heavy Chain General Information
Alternate Names
Myosin-11, MYH11
Molecular Weight
205kDa (MHC-1), 200kDa (MHC-2)
Chromosomal Location
16p13.11
Curated Database and Bioinformatic Data
Gene SymbolMYH11
Entrez Gene ID4629
Ensemble Gene IDENSG00000133392, ENSG00000276480
RefSeq Protein Accession(s)NP_001035203, XP_011520804, NP_001035202, NP_002465, NP_074035, XP_016878739
RefSeq mRNA Accession(s)XM_017023250, NM_001040114, XM_011522502, NM_002474, NM_022844, NM_001040113,
RefSeq Genomic Accession(s)NC_000016, NG_009299, NG_187607, NC_018927
UniProt ID(s)A0A024QZJ6, P35749, A0A024QZJ4
UniGene ID(s)A0A024QZJ6, P35749, A0A024QZJ4
HGNC ID(s)7569
Cosmic ID(s)MYH11
KEGG Gene ID(s)hsa:4629
PharmGKB ID(s)PA31367
General Description of Smooth Muscle Myosin Heavy Chain.
Smooth muscle myosin heavy chain (SM-MHC) is a cytoplasmic structural protein, which is a major component of the contractile apparatus in smooth muscle cells. Expression of smooth muscle myosin is developmentally regulated, appearing early in smooth muscle development,, is specific for smooth muscle development. Two isoforms of smooth muscle myosin heavy chain have been identified, designated MHC-1, MHC-2. The antibody may be useful for the study of breast tumors as the presence of an intact layer of myoepithelial cells is an important feature, which may distinguish benign breast lesions, carcinoma in situ from invasive tumors.

Human, Rat, and Broad Species Reactivity Anti-Smooth Muscle Myosin Heavy Chain Antibody Product Attributes

Species: Human, Rat, and Broad Species Reactivity
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-Smooth Muscle Myosin Heavy Chain Antibody Clone: MYH11/923
Clone MYH11/923 Host and Isotype: Mouse IgG1 kappa
Anti-Human, Rat, and Broad Species Reactivity Smooth Muscle Myosin Heavy Chain Positive Control Sample: Uterus or normal breast
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human MYH11 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Smooth Muscle Myosin Heavy Chain Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-MYH11 antibody staining is expected to be primarily localized to the cytosol and plasma membrane.

Observed Antibody Staining Data By Tissue Type:

Variations in Smooth Muscle Myosin Heavy Chain antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in myoepithelial cells in the breast and smooth muscle cells in the smooth muscle. More moderate antibody staining intensity was present in myoepithelial cells in the breast and smooth muscle cells in the smooth muscle. Low, but measureable presence of Smooth Muscle Myosin Heavy Chain could be seen in. We were unable to detect Smooth Muscle Myosin Heavy Chain in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's Smooth Muscle Myosin Heavy Chain Anti-Human, Rat Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Smooth Muscle Myosin Heavy Chain Antibody Clone MYH11/923

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