Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with Thymidylate Synthase Monoclonal Antibody (TS16 + TMS715).
Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with Thymidylate Synthase Monoclonal Antibody (TS16 + TMS715).

Anti-Thymidylate Synthase Antibody Clone TS106 + TMS715

$ 429.00
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SKU: 7298-MSM3
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
7298-MSM3-P1 Size: 100 ug, Tag: Unconjugated
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SKU: 7298-MSM3-P1
Thymidylate Synthase General Information
Alternate Names
Thymidylate synthetase, TYMS
Molecular Weight
Chromosomal Location
Curated Database and Bioinformatic Data
Gene SymbolTYMS
Entrez Gene ID7298
Ensemble Gene IDENSG00000176890
RefSeq Protein Accession(s)NP_001341797, NP_001062, NP_001341796
RefSeq mRNA Accession(s)NM_001354868 NM_001071, NM_001354867
RefSeq Genomic Accession(s)NG_028255, NC_000018, NC_018929,
UniProt ID(s)Q53Y97, P04818
UniGene ID(s)Q53Y97, P04818
HGNC ID(s)12441
Cosmic ID(s)TYMS
KEGG Gene ID(s)hsa:7298
PharmGKB ID(s)PA359
General Description of Thymidylate Synthase.
It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU, fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head, neck,, breast carcinomas.

Human Anti-Thymidylate Synthase Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (1-2ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-Thymidylate Synthase Antibody Clone: TS106 + TMS715
Clone TS106 + TMS715 Host and Isotype: Mouse IgG
Anti-Human Thymidylate Synthase Positive Control Sample: 5-FU-resistant colon carcinoma cell lines (NCI H630R10, NCI H630R1); 5-FU-resistant breast cancer cell lines, MCF-Ad5, MCF-Ad10. Testicular carcinomas.
Cellular Localization of Antibody Nuclear & Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human thymidylate synthase (TS106 & TMS715)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Thymidylate Synthase Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in Thymidylate Synthase antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in hematopoietic cells in the bone marrow and germinal center cells in the lymph node and tonsil. More moderate antibody staining intensity was present in hematopoietic cells in the bone marrow and germinal center cells in the lymph node and tonsil. Low, but measureable presence of Thymidylate Synthase could be seen inglandular cells in the breast, myoepithelial cells in the breast, respiratory epithelial cells in the bronchus, endothelial cells in the cerebral cortex, neuropil in cerebral cortex, glandular cells in the cervix, uterine, endothelial cells in the colon, glandular cells in the endometrium, squamous epithelial cells in the esophagus, glandular cells in the fallopian tube, myocytes in heart muscle, cells in the glomeruli in kidney, cells in the tubules in kidney, bile duct cells in the liver, hepatocytes in liver, ovarian stroma cells in the ovary, glandular cells in the prostate, myocytes in skeletal muscle, fibroblasts in skin, Langerhans in skin, melanocytes in skin, smooth muscle cells in the smooth muscle, fibroblasts in mesenchymal tissue, cells in the red pulp in spleen, cells in the white pulp in spleen and glandular cells in the thyroid gland. We were unable to detect Thymidylate Synthase in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Thymidylate Synthase expression as measured by anti-Thymidylate Synthase antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity ++ ++ ++ ++ ++ ++ ++ ++ + ++ ++ ++ ++ ++ ++ + ++ ++ ++ ++
TYMS Variability ++ ++ ++ + + ++ ++ + ++ ++ + ++ + + ++ ++ ++ ++ + +

Limitations and Warranty

enQuire Bio's Thymidylate Synthase Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Thymidylate Synthase Antibody Clone TS106 + TMS715