Immunohistochemical staining of Thyroid Peroxidase  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

Thyroid Peroxidase [MoAb47] Antibody (cGMP).

$ 135.00$ 975.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD205
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG1

Product NumberDescriptionPrice
QIVD205-0.1ml Size: 0.1 ml, Format: Concentrate $ 135.00
QIVD205-0.5ml Size: 0.5 ml, Format: Concentrate $ 585.00
QIVD205-1ml Size: 1 ml, Format: Concentrate $ 975.00
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Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
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SKU: QIVD205-0.1ml
Thyroid Peroxidase General Information
Alternate Names
Molecular Weight
103 kDa
Chromosomal Location
p25.3 [chr: 2] [chr_start: 1374066] [chr_end: 1543711] [strand: 1]; [chr: CHR_HSCHR2_4_CTG1] [chr_start: 1372594] [chr_end: 1540021] [strand: 1]
Curated Database and Bioinformatic Data
Gene SymbolTPO
Entrez Gene ID7173
RefSeq Protein Accession(s)NP_783652; NP_001193674; XP_011508683; NP_001193673; NP_783650; NP_000538; NP_783653
RefSeq mRNA Accession(s)XM_011510380; XM_024453091; NM_001206744; XM_024453085; XM_024453086; XM_024453087; NM_000547; XM_024453090; NM_001206745; NM_175721; XM_024453088; XM_024453092; NM_175719; NM_175720; XM_024453089; XM_024453093; NM_175722
RefSeq Genomic Accession(s); NC_000002; NT_187529; NG_011581
UniProt ID(s)P07202
PharmGKB ID(s)PA36694
KEGG Gene ID(s)hsa:7173
Associated Diseases (KEGG IDs)An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.; Thyroid dyshormonogenesis 2A (TDH2A) [MIM:274500]: A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. {ECO:0000269|PubMed:10084596, ECO:0000269|PubMed:10468986, ECO:0000269|PubMed:11061528, ECO:0000269|PubMed:11415848, ECO:0000269|PubMed:11874711, ECO:0000269|PubMed:11916616, ECO:0000269|PubMed:12213873, ECO:0000269|PubMed:12490071, ECO:0000269|PubMed:12843174, ECO:0000269|PubMed:12864797, ECO:0000269|PubMed:12938097, ECO:0000269|PubMed:16284446, ECO:0000269|PubMed:16684826, ECO:0000269|PubMed:27305979, ECO:0000269|PubMed:7550241, ECO:0000269|PubMed:9024270, ECO:0000269|PubMed:9924196}. The disease is caused by mutations affecting the gene represented in this entry.
General Description of Thyroid Peroxidase .
Thyroid peroxidase (TPO) is a transmembrane protein of 107kDa containing a heme prosthetic group. It is present as a dimer on the apical surface of thyroid follicular cells. TPO is the primary enzyme involved in thyroid hormone synthesis. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:10-1:25
Pretreatment EDTA Buffer pH 8.0
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal
Anti-Thyroid Peroxidase Antibody Clone: MoAb47
Host and Isotype: Mouse IgG1
Recommended Positive Control Sample: Thyroid
Cellular Localization of Antibody MoAb47 Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Human thyroid peroxidase (hTPO) purified from thyroid microsomes by immunoaffinity chromatography.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Thyroid Peroxidase Information for Pathologists

Summary:

Thyroid peroxidase (TPO) is an enzyme involved in TH synthesis. It is expressed on the apical surface of thyroid folliular cells.

Common Uses By Pathologists:

Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. TPO staining may help differentiate between benign and malignant thyroid tumors. TPO staining is also useful for classification of solitary cold thyroid nodules in FNA cytology samples.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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Thyroid Peroxidase [MoAb47] Antibody (cGMP).