Formalin-fixed, paraffin-embedded human Erdheim Chester disease (also known as polyostotic lerosing histiocytosis) stained with TNF alpha Monoclonal Antibody (TNFA/1172).

Formalin-fixed, paraffin-embedded Rat Stomach stained with TNF alpha Monoclonal Antibody (TNFA/1172)

Formalin-fixed, paraffin-embedded Rat Pancreas stained with TNF alpha Monoclonal Antibody (TNFA/1172)

Anti-TNF-alpha Antibody Clone TNFA/1172

Name: Anti-TNF-alpha Antibody Clone TNFA/1172
Brand: enQuire Bio
Price: 488 USD
Availability: InStock

$ 429.00

Please Select Product Options Below To View The Catalog Number.

SKU: 7124-MSM12
Species: Human and Rat
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgM kappa
Mass Spec Validated?: Not MS Validated

Product Number	Description	Price
7124-MSM12-P1	Size: 100 ug, Tag: Unconjugated

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In Stock.

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Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: 7124-MSM12-P1

TNF-alpha General Information
Alternate Names
Tumor necrosis factor, TNF, TNFalpha, TNFa, TNF alpha, TNF?
Molecular Weight
17kDa
Chromosomal Location
6p21.33
Curated Database and Bioinformatic Data
Gene Symbol	TNF
Entrez Gene ID	7124
Ensemble Gene ID	ENSG00000232810, ENSG00000230108, ENSG00000223952, ENSG00000206439, ENSG00000228849, ENSG00000228978, ENSG00000228321, ENSG00000204490
RefSeq Protein Accession(s)	NP_000585
RefSeq mRNA Accession(s)	NM_000594
RefSeq Genomic Accession(s)	NG_167244, NG_167248, NC_018917, NG_167246, NG_167247, NG_007462, NG_113891, NG_167245, NG_167249, NC_000006
UniProt ID(s)	Q5STB3, P01375
UniGene ID(s)	Q5STB3, P01375
HGNC ID(s)	11892
Cosmic ID(s)	TNF
KEGG Gene ID(s)	hsa:7124
PharmGKB ID(s)	PA435
General Description of TNF-alpha.
This MAb recognizes human 17-26kDa protein, which is identified as cytokine TNF-alpha (Tumor Necrosis Factor-alpha). TNF-alpha can be expressed as a 17kDa free molecule, or as a 26kDa membrane protein. TNF-alpha is a protein secreted by lipopolysaccharide-stimulated macrophages,, causes tumor necrosis when injected into tumor bearing mice. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts, other cell lines, activating polymorphonuclear neutrophils, osteoclasts,, induction of interleukin 1, prostaglandin E2, collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers, AIDS Related Complex.

Human and Rat Anti-TNF-alpha Antibody Product Attributes

Species: Human and Rat

Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).

Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-paraffin) (2-4ug of antibody/ml for 30 min at RT)

Clonality: Monoclonal

Anti-TNF-alpha Antibody Clone: TNFA/1172

Clone TNFA/1172 Host and Isotype: Mouse IgM kappa

Anti-Human and Rat TNF-alpha Positive Control Sample: HeLa, HL-60, or A431 cells. Pancreas or Histiocytoma

Cellular Localization of Antibody Cytoplasmic, extracellular (secreted)

Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.

Antibody Concentration: 200ug/ml

Antibody Purification Method:Protein A/G Purified

Immunogen: Recombinant full-length human TNF-alpha protein

Storage Conditions: Store at 2 to 8Â° C (refrigerate). Stable for 24 months when properly stored.

TNF-alpha Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's TNF-alpha Anti-Human, Rat Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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