Formalin-fixed, paraffin-embedded human Gall Bladder stained with TOX3 Monoclonal Antibody (TOX3/1123).
Formalin-fixed, paraffin-embedded human Gall Bladder stained with TOX3 Monoclonal Antibody (TOX3/1123).Formalin-fixed, paraffin-embedded human Cervical Carcinoma stained with TOX3 Monoclonal Antibody (TOX3/1123).

Anti-TOX3 / TNRC9 Antibody Clone TOX3/1123

$ 298.00
Please Select Product Options Below To View The Catalog Number.

SKU: 27324-MSM1
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2b kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 27324-MSM1-P1
TOX3 / TNRC9 General Information
Alternate Names
TOX high mobility group box family member 3, TOX3
Molecular Weight
63kDa
Chromosomal Location
16q12.1
Curated Database and Bioinformatic Data
Gene SymbolTOX3
Entrez Gene ID27324
Ensemble Gene IDENSG00000103460
RefSeq Protein Accession(s)XP_005255949, XP_016878631, XP_011521304, NP_001139660, NP_001073899
RefSeq mRNA Accession(s)NM_001080430, XM_005255892, XM_017023142, NM_001146188
RefSeq Genomic Accession(s)NG_012623, NC_000016, NC_018927
UniProt ID(s)O15405
UniGene ID(s)O15405
HGNC ID(s)11972
Cosmic ID(s)TOX3
KEGG Gene ID(s)hsa:27324
PharmGKB ID(s)PA162406752
General Description of TOX3 / TNRC9.
It recognizes a 63kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility, is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain, forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts, repression of pro-apoptotic transcripts.

Human Anti-TOX3 / TNRC9 Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-TOX3 / TNRC9 Antibody Clone: TOX3/1123
Clone TOX3/1123 Host and Isotype: Mouse IgG2b kappa
Anti-Human TOX3 / TNRC9 Positive Control Sample: SH-SY5Y, MDA-MB-435 cells. Brain or breast or gastric Carcinoma.
Cellular Localization of Antibody Cytoplasmic & Nuclear
Buffer and Stabilizer: 1mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant fragment (139 Amino acid residues around aa 200-400) of human TOX3 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

TOX3 / TNRC9 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-TOX3 antibody staining is expected to be primarily localized to the nucleoplasm.

Observed Antibody Staining Data By Tissue Type:

Variations in TOX3 / TNRC9 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in Purkinje cells in the cerebellum. More moderate antibody staining intensity was present in Purkinje cells in the cerebellum. Low, but measureable presence of TOX3 / TNRC9 could be seen inglandular cells in the appendix, glial cells in the caudate nucleus, cells in the molecular layer in cerebellum, glial cells in the cerebral cortex, glandular cells in the colon, peripheral nerve/ganglion in colon, glial cells in the hippocampus, cells in the tubules in kidney, glandular cells in the prostate, rectum and stomach and Leydig cells in the testis. We were unable to detect TOX3 / TNRC9 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of TOX3 / TNRC9 expression as measured by anti-TOX3 / TNRC9 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - - - - - - - - - - - - - -
TOX3 Variability + ++ ++ ++ + + ++ + + + + + ++ + + ++ + + + ++

Limitations and Warranty

enQuire Bio's TOX3 / TNRC9 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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