Immunohistochemical staining of Tyrosinase, Melanoma Marker  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

Tyrosinase, Melanoma Marker [T311] Antibody (cGMP).

$ 135.00$ 755.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD203
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG2a

Product NumberDescriptionPrice
QIVD203-0.1ml Size: 0.1 ml, Format: Concentrate $ 158.00
QIVD203-0.5ml Size: 0.5 ml, Format: Concentrate $ 498.00
QIVD203-1ml Size: 1 ml, Format: Concentrate $ 848.00
QIVD203-6ml Size: 6 ml, Format: Predilute $ 338.00
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SKU: QIVD203-0.1ml
Tyrosinase, Melanoma Marker General Information
Alternate Names
Molecular Weight
60.4 kDa
Chromosomal Location
q14.3 [chr: 11] [chr_start: 89177875] [chr_end: 89295759] [strand: 1]
Curated Database and Bioinformatic Data
Gene SymbolTYR
Entrez Gene ID7299
RefSeq Protein Accession(s)NP_000363
RefSeq mRNA Accession(s)NM_000372; XM_011542970;
RefSeq Genomic Accession(s)NC_000011; NG_008748
UniProt ID(s)P14679
PharmGKB ID(s)PA37095
KEGG Gene ID(s)hsa:7299
Associated Diseases (KEGG IDs)Albinism, oculocutaneous, 1A (OCA1A) [MIM:203100]: An autosomal recessive disorder in which the biosynthesis of melanin pigment is absent in skin, hair, and eyes. It is characterized by complete lack of tyrosinase activity due to production of an inactive enzyme. Patients present with a life-long absence of melanin pigment after birth, and manifest increased sensitivity to ultraviolet radiation with predisposition to skin cancer. Visual anomalies include decreased acuity, nystagmus, strabismus and photophobia. {ECO:0000269|PubMed:10571953, ECO:0000269|PubMed:10671066, ECO:0000269|PubMed:10987646, ECO:0000269|PubMed:11295837, ECO:0000269|PubMed:11858948, ECO:0000269|PubMed:1487241, ECO:0000269|PubMed:15146472, ECO:0000269|PubMed:1642278, ECO:0000269|PubMed:1899321, ECO:0000269|PubMed:1943686, ECO:0000269|PubMed:1970634, ECO:0000269|PubMed:22981120, ECO:0000269|PubMed:2342539, ECO:0000269|PubMed:23504663, ECO:0000269|PubMed:24934919, ECO:0000269|PubMed:7902671, ECO:0000269|PubMed:7955413, ECO:0000269|PubMed:8128955, ECO:0000269|PubMed:8644824, ECO:0000269|PubMed:9259202}. The disease is caused by mutations affecting the gene represented in this entry.; Albinism, oculocutaneous, 1B (OCA1B) [MIM:606952]: An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. It is characterized by partial lack of tyrosinase activity. Patients have white hair at birth that rapidly turns yellow or blond. They manifest the development of minimal-to-moderate amounts of cutaneous and ocular pigment. Some patients may have with white hair in the warmer areas (scalp and axilla) and progressively darker hair in the cooler areas (extremities). This variant phenotype is due to a loss of tyrosinase activity above 35-37 degrees C. {ECO:0000269|PubMed:10987646, ECO:0000269|PubMed:1900309, ECO:0000269|PubMed:1903591, ECO:0000269|PubMed:8128955}. The disease is caused by mutations affecting the gene represented in this entry.
General Description of Tyrosinase, Melanoma Marker .
This antibody is specific to a cluster of proteins between 70-80 kDa known as tyrosinase. This antibody does not show any cross-reaction with MAGE-1 and tyrosinase-related protein-1, TRP-1/gp75. Staining of melanomas with this antibody showed tyrosinase in melanotic as well as amelanotic variants.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:50-1:100
Pretreatment EDTA Buffer pH 8.0
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal
Anti-Tyrosinase, Melanoma Marker Antibody Clone: T311
Host and Isotype: Mouse IgG2a
Recommended Positive Control Sample: Melanoma
Cellular Localization of Antibody T311 Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: BALB/C mice were injected with a recombinant tyrosinase protein.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Tyrosinase, Melanoma Marker Information for Pathologists

Summary:

Also called T311 (for immunohistochemistry). Melanocyte specific antigen important in melanin synthesis and melanosome formation. Interpretation: cytoplasmic staining. Uses by pathologists Identification of melanocytic neoplasms.

Common Uses By Pathologists:

Identification of melanocytic neoplasms. Microscopic (histologic) images Images hosted on other servers:. Normal skin. prominent melanocytes (a);.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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Tyrosinase, Melanoma Marker [T311] Antibody (cGMP).