Formalin-fixed, paraffin-embedded human Melanoma stained with TYRP1 Monoclonal Antibody (SPM611)
Formalin-fixed, paraffin-embedded human Melanoma stained with TYRP1 Monoclonal Antibody (SPM611)

Anti-Tyrosinase-Related Protein-1 Antibody Clone SPM611

$ 488.00
Please Select Product Options Below To View The Catalog Number.

SKU: 7306-MSM2X
Species: Human and Mouse
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2a kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
7306-MSM2X-P1 Size: 100 ug, Tag: Unconjugated
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SKU: 7306-MSM2X-P1
Tyrosinase-Related Protein-1 General Information
Alternate Names
Tyrosinase-related protein 1, TYRP1
Molecular Weight
Chromosomal Location
Curated Database and Bioinformatic Data
Gene SymbolTYRP1
Entrez Gene ID7306
Ensemble Gene IDENSG00000107165
RefSeq Protein Accession(s)NP_000541
RefSeq mRNA Accession(s)NM_000550, XR_001746372,
RefSeq Genomic Accession(s)NG_011705, NC_018920, NC_000009
UniProt ID(s)P17643
UniGene ID(s)P17643
HGNC ID(s)12450
Cosmic ID(s)TYRP1
KEGG Gene ID(s)hsa:7306
PharmGKB ID(s)PA37101
General Description of Tyrosinase-Related Protein-1.
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes, nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein, modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure, affects melanocyte proliferation, cell death.

Human and Mouse Anti-Tyrosinase-Related Protein-1 Antibody Product Attributes

Species: Human and Mouse
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (2-4ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-Tyrosinase-Related Protein-1 Antibody Clone: SPM611
Clone SPM611 Host and Isotype: Mouse IgG2a kappa
Anti-Human and Mouse Tyrosinase-Related Protein-1 Positive Control Sample: SK-MEL-23, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells or Melanoma.
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant full-length human TYRP1 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Tyrosinase-Related Protein-1 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-TYRP1 antibody staining is expected to be primarily localized to the vesicles.

Observed Antibody Staining Data By Tissue Type:

Variations in Tyrosinase-Related Protein-1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in melanocytes in skin. More moderate antibody staining intensity was present in melanocytes in skin. Low, but measureable presence of Tyrosinase-Related Protein-1 could be seen in. We were unable to detect Tyrosinase-Related Protein-1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Tyrosinase-Related Protein-1 expression as measured by anti-Tyrosinase-Related Protein-1 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - - - - ++ - - - - - - - - -
TYRP1 Variability + + + ++ + + ++ + + + ++ + + + + ++ + ++ + +

Limitations and Warranty

enQuire Bio's Tyrosinase-Related Protein-1 Anti-Human, Mouse Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Tyrosinase-Related Protein-1 Antibody Clone SPM611