FFPE human parathyroid mass sections stained with 100 ul anti-VEGI (clone VEGI/1283) at 1:50. HIER epitope retrieval prior to staining was performed in 10mM Tris 1mM EDTA, pH 9.0.Formalin-fixed, paraffin-embedded human Parathyroid Mass stained with VEGI Monoclonal Antibody (VEGI /1283).

Anti-VEGI Antibody Clone VEGI/1283

$ 199.00$ 459.00
Please Select Product Options Below To View The Catalog Number.

SKU: 9966-MSM1
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
9966-MSM1-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
9966-MSM1-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
9966-MSM1-P2 Size: 200 ug, Tag: Unconjugated $ 459.00
Shipping Information
In Stock.
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:


Bioactivity (test results eg. IU/ml):

SKU: 9966-MSM1-P0
VEGI General Information
Alternate Names
Vascular endothelial growth inhibitor, VEGI, TNF-like ligand 1A, TL1A, TNF superfamily member 15, TNFSF15
Molecular Weight
Chromosomal Location
Curated Database and Bioinformatic Data
Gene SymbolTNFSF15
Entrez Gene ID9966
Ensemble Gene IDENSG00000181634
RefSeq Protein Accession(s)NP_005109, NP_001191273
RefSeq mRNA Accession(s)NM_001204344, NM_005118
RefSeq Genomic Accession(s)NG_011488, NC_000009, NC_018920
UniProt ID(s)O95150, A0A0U5JA19
UniGene ID(s)O95150, A0A0U5JA19
HGNC ID(s)11931
Cosmic ID(s)TNFSF15
KEGG Gene ID(s)hsa:9966
PharmGKB ID(s)PA36623
General Description of VEGI.
VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.

Human Anti-VEGI Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-VEGI Antibody Clone: VEGI/1283
Clone VEGI/1283 Host and Isotype: Mouse IgG1 kappa
Anti-Human VEGI Positive Control Sample: Endothelial cells. Colon, intestine, placenta, lung, liver, kidney, pancreas, spleen and prostate.
Cellular Localization of Antibody Secreted and Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length VEGI fragment
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

VEGI Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-TNFSF15 antibody staining is expected to be primarily localized to the cytosol, nuclear membrane and nucleus.

Observed Antibody Staining Data By Tissue Type:

Variations in VEGI antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of VEGI could be seen inglandular cells in the breast, myoepithelial cells in the breast, neuronal cells in the caudate nucleus, endothelial cells in the cerebral cortex, squamous epithelial cells in the cervix, uterine, endothelial cells in the colon, cells in the endometrial stroma in endometrium, cells in the glomeruli in kidney, bile duct cells in the liver, hepatocytes in liver, pneumocytes in lung, squamous epithelial cells in the oral mucosa, exocrine glandular cells in the pancreas, glandular cells in the salivary gland, keratinocytes in skin, melanocytes in skin, fibroblasts in mesenchymal tissue, germinal center cells in the tonsil, non-germinal center cells in the tonsil and squamous epithelial cells in the tonsil and vagina. We were unable to detect VEGI in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of VEGI expression as measured by anti-VEGI antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity + + + + ++ + + + + - + ++ + + - + + - ++ +
TNFSF15 Variability + ++ ++ ++ ++ +++ ++ ++ ++ ++ ++ ++ ++ +++ ++ ++ ++ ++ ++ ++

Limitations and Warranty

enQuire Bio's VEGI Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

There are no reviews yet.

Be the first to review “Anti-VEGI Antibody Clone VEGI/1283”

Your email address will not be published. Required fields are marked *

Share a Protocol (View Reviewed Protocols Below)

Protocol Title




  protocol submission gif
enQuire Bio, LLC   8420 S Continental Divide Rd, #202   Littleton, CO 80127
Chat: See lower right corner. | enquire@enquirebio.com | Fax: 1-720-897-3730
Customer Service Available M-F 8AM-6PM MST or 24/7 Via Email

Anti-VEGI Antibody Clone VEGI/1283

https://enquirebio.com/wp-content/uploads/2019/01/VEGI IHC human Colon Carcinoma (VEGI 1283)-300x225.jpghttps://enquirebio.com/wp-content/uploads/2019/01/VEGI IHC human Parathyroid Mass (VEGI 1283)-300x225.jpghttps://enquirebio.com/wp-content/uploads/2017/10/enQuire-Bio-9966-MSM1-P0-anti-VEGI-antibody-300x225.jpeg