Western Blot Analysis A) Recombinant Protein (B) human lung lysate Using Monoclonal Antibody MAb (VWF/1465)
Western Blot Analysis A) Recombinant Protein (B) human lung lysate Using Monoclonal Antibody MAb (VWF/1465)

Anti-von Willebrand Factor Antibody Clone VWF/1465

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 7450-MSM5
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
7450-MSM5-P0 Size: 20 ug, Tag: Unconjugated $ 118.00
7450-MSM5-P1 Size: 100 ug, Tag: Unconjugated $ 298.00
7450-MSM5-P2 Size: 200 ug, Tag: Unconjugated $ 418.00
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In Stock.
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
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SKU: 7450-MSM5-P0
von Willebrand Factor General Information
Alternate Names
Von Willebrand Factor, vWF
Molecular Weight
250kDa
Chromosomal Location
12p13.31
Curated Database and Bioinformatic Data
Gene SymbolVWF
Entrez Gene ID7450
Ensemble Gene IDENSG00000110799
RefSeq Protein Accession(s)NP_000543
RefSeq mRNA Accession(s)NM_000552,
RefSeq Genomic Accession(s)NC_000012, NC_018923, NG_009072
UniProt ID(s)P04275
UniGene ID(s)P04275
HGNC ID(s)12726
Cosmic ID(s)VWF
KEGG Gene ID(s)hsa:7450
PharmGKB ID(s)PA37337
General Description of von Willebrand Factor.
von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposi s sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contain this antigen.

Human Anti-von Willebrand Factor Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-von Willebrand Factor Antibody Clone: VWF/1465
Clone VWF/1465 Host and Isotype: Mouse IgG1
Anti-Human von Willebrand Factor Positive Control Sample: HUVEC cells or Tonsil
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant fragment of human vWF protein (aa1815-1939)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

von Willebrand Factor Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in von Willebrand Factor antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in endothelial cells in the cerebral cortex, colon. More moderate antibody staining intensity was present in endothelial cells in the cerebral cortex, colon. Low, but measureable presence of von Willebrand Factor could be seen infibroblasts in skin, keratinocytes in skin, Langerhans in skin, melanocytes in skin, adipocytes in mesenchymal tissue and fibroblasts in mesenchymal tissue. We were unable to detect von Willebrand Factor in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's von Willebrand Factor Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-von Willebrand Factor Antibody Clone VWF/1465

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