SDS-PAGE Analysis CD1a Mouse Recombinant Monoclonal Antibody (rC1A/711).Confirmation of Purity and Integrity of Antibody.
SDS-PAGE Analysis CD1a Mouse Recombinant Monoclonal Antibody (rC1A/711).Confirmation of Purity and Integrity of Antibody.Formalin-fixed, paraffin-embedded human Skin Stained with CD1a Mouse Recombinant Monoclonal Antibody (rC1A/711).

CD1a / HTA1 (Mature Langerhans Cells Marker) MonoSpecific Antibody

$ 199.00$ 429.00
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SKU: 909-MSM8
Species: Human
Tested Applications: IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG1, kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 909-MSM8-P0
CD1a / HTA1 (Mature Langerhans Cells Marker) General Information
Alternate Names
Cortical thymocyte antigen CD1A, Epidermal dendritic cell marker CD1a antibody, FCB6, HTA1, T cell surface antigen T6 / Leu 6, T-Cell Surface Glycoprotein CD1A
Molecular Weight
49kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol909
Entrez Gene IDCD1A
UniProt ID(s)P06126
UniGene ID(s)Hs1309
COSMIC ID Link(s)CD1A
KEGG Gene ID(s)hsa:909
General Description of CD1a / HTA1 (Mature Langerhans Cells Marker).
At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).

Human Anti-CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody Product Attributes

Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody Clone: rC1A/711
Clone rC1A/711 Host and Isotype: Mouse IgG1, kappa
Anti-Human CD1a / HTA1 (Mature Langerhans Cells Marker) Positive Control Sample: MOLT-4 cells. Paracortex in a tonsil or a reactive lymph node.
Cellular Localization of Antibody rC1A/711 Staining: Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human CD1a protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

CD1a / HTA1 (Mature Langerhans Cells Marker) Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD1a / HTA1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in Langerhans in skin. More moderate antibody staining intensity was present in Langerhans in skin. Low, but measureable presence of CD1a / HTA1 could be seen infibroblasts in skin. We were unable to detect CD1a / HTA1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of CD1a / HTA1 expression as measured by anti-CD1a / HTA1 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - - - - - - + - - - + + - +
CD1A Variability + + + + + + + + + + + + + + ++ + ++ + + ++

Limitations and Warranty

enQuire Bio's product, CD1a / HTA1 (Mature Langerhans Cells Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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