Analysis of Protein Array containing more than 19,000 full-lengthhuman proteins using  CDX2 Mouse Monoclonal Antibody (PCRP-CDX2-1A3) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing more than 19,000 full-lengthhuman proteins using  CDX2 Mouse Monoclonal Antibody (PCRP-CDX2-1A3) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.SDS-PAGE Analysis Purified CDX2 Mouse Monoclonal Antibody (PCRP-CDX2-1A3).Confirmation of Purity and Integrity of Antibody.

CDX2 / Caudal Type Homeobox 2 (GI Epithelial Marker) Ultraspecific Antibody

Tested against >20,000 Human Proteins

$ 199.00$ 429.00
Please Select Product Options Below To View The Catalog Number.

SKU: 1045-MSM3
Species: Human
Tested Applications: IP, WB, IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
1045-MSM3-P0 Size: 20 ug, Tag: Unconjugated $ 228.00
1045-MSM3-P1 Size: 100 ug, Tag: Unconjugated $ 488.00
1045-MSM3-P1ABX Size: 100 ug, Tag: Unconjugated $ 488.00
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SKU: 1045-MSM3-P0
CDX2 / Caudal Type Homeobox 2 (GI Epithelial Marker) General Information
Alternate Names
Caudal type homeobox 2; Caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2;CDX2
Molecular Weight
40kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol1045
Entrez Gene IDCDX2
UniProt ID(s)Q99626
UniGene ID(s)Hs174249
COSMIC ID Link(s)CDX2
KEGG Gene ID(s)hsa:1045
General Description of CDX2 / Caudal Type Homeobox 2 (GI Epithelial Marker).
The specificity of this monoclonal antibody to its intended target was validated by HuProtTMArray, containing more than 19,000, full-length human proteins.The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.

Human Anti-CDX2 / Caudal Type Homeobox 2 (GI Epithelial Marker) Antibody Product Attributes

Species: Human
Tested Applications: IP, WB, IHC.
Clonality: Monoclonal
Anti-CDX2 / Caudal Type Homeobox 2 (GI Epithelial Marker) Antibody Clone: PCRP-CDX2-1A3
Clone PCRP-CDX2-1A3 Host and Isotype: Mouse IgG1
Anti-Human CDX2 / Caudal Type Homeobox 2 (GI Epithelial Marker) Positive Control Sample: HT29 cells or Colon Carcinoma
Cellular Localization of Antibody PCRP-CDX2-1A3 Staining: Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human CDX2protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

CDX2 / Caudal Type Homeobox 2 (GI Epithelial Marker) Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-CDX2 antibody staining is expected to be primarily localized to the nucleoplasm. There is variability in either the signal strength or the localization of signal in nucleoplasm from cell to cell.

Observed Antibody Staining Data By Tissue Type:

Variations in CDX2 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the appendix, colon, duodenum, rectum. More moderate antibody staining intensity was present in glandular cells in the appendix, colon, duodenum, rectum. Low, but measureable presence of CDX2 could be seen in. We were unable to detect CDX2 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's product, CDX2 / Caudal Type Homeobox 2 (GI Epithelial Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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Tested against >20,000 Human Proteins

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CDX2 / Caudal Type Homeobox 2 (GI Epithelial Marker) Ultraspecific Antibody

Tested against >20,000 Human Proteins

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